Inhibition of Toll-Like Receptor 2-Mediated Interleukin-8 Production in Cystic Fibrosis Airway Epithelial Cells via the α7-Nicotinic Acetylcholine Receptor
Joint Authors
Ramsay, Hugh
McElvaney, Noel G.
Wells, Robert J.
O'Neill, Shane J.
Greene, Catherine M.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Cystic Fibrosis (CF) is an inherited disorder characterised by chronic inflammation of the airways.
The lung manifestations of CF include colonization with Pseudomonas aeruginosa and Staphylococcus aureus leading to neutrophil-dominated airway inflammation and tissue damage.
Inflammation in the CF lung is initiated by microbial components which activate the innate immune response via Toll-like receptors (TLRs), increasing airway epithelial cell production of proinflammatory mediators such as the neutrophil chemokine interleukin-8 (IL-8).
Thus modulation of TLR function represents a therapeutic approach for CF.
Nicotine is a naturally occurring plant alkaloid.
Although it is negatively associated with cigarette smoking and cardiovascular damage, nicotine also has anti-inflammatory properties.
Here we investigate the inhibitory capacity of nicotine against TLR2- and TLR4-induced IL-8 production by CFTE29o- airway epithelial cells, determine the role of α7-nAChR (nicotinic acetylcholine receptor) in these events, and provide data to support the potential use of safe nicotine analogues as anti-inflammatories for CF.
American Psychological Association (APA)
Greene, Catherine M.& Ramsay, Hugh& Wells, Robert J.& O'Neill, Shane J.& McElvaney, Noel G.. 2010. Inhibition of Toll-Like Receptor 2-Mediated Interleukin-8 Production in Cystic Fibrosis Airway Epithelial Cells via the α7-Nicotinic Acetylcholine Receptor. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-470996
Modern Language Association (MLA)
Greene, Catherine M.…[et al.]. Inhibition of Toll-Like Receptor 2-Mediated Interleukin-8 Production in Cystic Fibrosis Airway Epithelial Cells via the α7-Nicotinic Acetylcholine Receptor. Mediators of Inflammation No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-470996
American Medical Association (AMA)
Greene, Catherine M.& Ramsay, Hugh& Wells, Robert J.& O'Neill, Shane J.& McElvaney, Noel G.. Inhibition of Toll-Like Receptor 2-Mediated Interleukin-8 Production in Cystic Fibrosis Airway Epithelial Cells via the α7-Nicotinic Acetylcholine Receptor. Mediators of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-470996
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470996