Is There a Role for Postmastectomy Radiation Therapy in Ductal Carcinoma In Situ?
Joint Authors
Boolbol, Susan K.
Harrison, Louis B.
Gillego, Alyssa
Portenoy, Jason
Chadha, Manjeet
Source
International Journal of Surgical Oncology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-13
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
DCIS treated by mastectomy ensures high local control rates.
There is limited data on risk for relapse and lack of clear indication for adjuvant radiation therapy (RT).
We report a retrospective review on a population of DCIS patients treated with mastectomy.
The objective was to identify the overall incidence of relapse, risk factors for local recurrence, and accordingly for whom adjuvant postmastectomy RT may be considered.
Methods.
This is an IRB-approved retrospective study on a prospective breast cancer database.
From 1997 to 2007, we identified 969 patients with diagnoses of DCIS, among them 211 breasts in 207 patients were treated with mastectomy and comprise the study group.
Results.
With a median followup of 55 months (4.6 years) the 10-year relapse-free survival is 97%.
Two of 211 breasts (0.9%) treated with mastectomy developed a local-regional recurrence.
Both the relapses were among patients defined as having <1 mm final mastectomy margin.
Conclusions.
The rare local relapse after mastectomy limits our ability to reliably identify risk factors for relapse.
The consideration for postmastectomy RT should be based on an individualized risk evaluating surgical technique used, presence of BRCA mutation, grade and extent of tumor, and proximity of lesion to the margin of resection.
American Psychological Association (APA)
Chadha, Manjeet& Portenoy, Jason& Boolbol, Susan K.& Gillego, Alyssa& Harrison, Louis B.. 2012. Is There a Role for Postmastectomy Radiation Therapy in Ductal Carcinoma In Situ?. International Journal of Surgical Oncology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-471010
Modern Language Association (MLA)
Chadha, Manjeet…[et al.]. Is There a Role for Postmastectomy Radiation Therapy in Ductal Carcinoma In Situ?. International Journal of Surgical Oncology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-471010
American Medical Association (AMA)
Chadha, Manjeet& Portenoy, Jason& Boolbol, Susan K.& Gillego, Alyssa& Harrison, Louis B.. Is There a Role for Postmastectomy Radiation Therapy in Ductal Carcinoma In Situ?. International Journal of Surgical Oncology. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-471010
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471010