Ipilimumab : A First-in-Class T-Cell Potentiator for Metastatic Melanoma
Author
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Ipilimumab, a fully human anti-cytotoxic T-lymphocyte antigen-4 monoclonal antibody that potentiates antitumor T-cell responses, has demonstrated improved survival in previously treated and treatment-naïve patients with unresectable stage III/IV melanoma.
Survival benefit has also been shown in diverse patient populations, including those with brain metastases.
In 2011, ipilimumab (3 mg/kg every 3 weeks for 4 doses) was approved by the Food and Drug Administration for unresectable or metastatic melanoma.
Ipilimumab can induce novel response patterns for which immune-related response criteria have been proposed.
irAEs are common but are usually low grade; higher grades can be severe and life-threatening.
irAEs are usually manageable using established guidelines emphasizing vigilance and prompt intervention.
This agent provides an additional therapeutic option in metastatic melanoma, and guidelines for management of adverse events facilitate clinical implementation of this new agent.
American Psychological Association (APA)
Chmielowski, Bartosz. 2013. Ipilimumab : A First-in-Class T-Cell Potentiator for Metastatic Melanoma. Journal of Skin Cancer،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-471045
Modern Language Association (MLA)
Chmielowski, Bartosz. Ipilimumab : A First-in-Class T-Cell Potentiator for Metastatic Melanoma. Journal of Skin Cancer No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-471045
American Medical Association (AMA)
Chmielowski, Bartosz. Ipilimumab : A First-in-Class T-Cell Potentiator for Metastatic Melanoma. Journal of Skin Cancer. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-471045
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471045