Potential Impact of B Cells on T Cell Function in Multiple Sclerosis
Joint Authors
Source
Multiple Sclerosis International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Multiple sclerosis is a chronic debilitating autoimmune disease of the central nervous system.
The contribution of B cells in the pathoetiology of MS has recently been highlighted by the emergence of rituximab, an anti-CD20 monoclonal antibody that specifically depletes B cells, as a potent immunomodulatory therapy for the treatment of MS.
However, a clearer understanding of the impact B cells have on the neuro-inflammatory component of MS pathogenesis is needed in order to develop novel therapeutics whose affects on B cells would be beneficial and not harmful.
Since T cells are known mediators of the pathology of MS, the goal of this review is to summarize what is known about the interactions between B cells and T cells, and how current and emerging immunotherapies may impact B-T cell interactions in MS.
American Psychological Association (APA)
Ireland, Sara& Monson, Nancy. 2011. Potential Impact of B Cells on T Cell Function in Multiple Sclerosis. Multiple Sclerosis International،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-471056
Modern Language Association (MLA)
Ireland, Sara& Monson, Nancy. Potential Impact of B Cells on T Cell Function in Multiple Sclerosis. Multiple Sclerosis International No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-471056
American Medical Association (AMA)
Ireland, Sara& Monson, Nancy. Potential Impact of B Cells on T Cell Function in Multiple Sclerosis. Multiple Sclerosis International. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-471056
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471056