Effects of Cisplatin in Neuroblastoma Rat Cells : Damage to Cellular Organelles
Joint Authors
Santin, Giada
Bernocchi, Graziella
Barni, Sergio
Veneroni, Paola
Bottone, Maria Grazia
Scietti, Luigi
Source
International Journal of Cell Biology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Cisplatin (cisPt) is a chemotherapy agent used as a treatment for several types of cancer.
The main cytotoxic effect of cisplatin is generally accepted to be DNA damage.
Recently, the mechanism by which cisPt generates the cascade of events involved in the apoptotic process has been demonstrated.
In particular it has been shown that some organelles are cisPt target and are involved in cell death.
This paper aims to describe the morphological and functional changes of the Golgi apparatus and lysosomes during apoptosis induced in neuronal rat cells (B50) by cisplatin.
The results obtained show that the cellular organelles are the target of cisPt, so their damage can induce cell death.
American Psychological Association (APA)
Santin, Giada& Scietti, Luigi& Veneroni, Paola& Barni, Sergio& Bernocchi, Graziella& Bottone, Maria Grazia. 2012. Effects of Cisplatin in Neuroblastoma Rat Cells : Damage to Cellular Organelles. International Journal of Cell Biology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-471066
Modern Language Association (MLA)
Santin, Giada…[et al.]. Effects of Cisplatin in Neuroblastoma Rat Cells : Damage to Cellular Organelles. International Journal of Cell Biology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-471066
American Medical Association (AMA)
Santin, Giada& Scietti, Luigi& Veneroni, Paola& Barni, Sergio& Bernocchi, Graziella& Bottone, Maria Grazia. Effects of Cisplatin in Neuroblastoma Rat Cells : Damage to Cellular Organelles. International Journal of Cell Biology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-471066
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471066