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The LLNA : A Brief Review of Recent Advances and Limitations
Joint Authors
Meade, B. Jean
Anderson, Stacey E.
Siegel, Paul D.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Allergic contact dermatitis is the second most commonly reported occupational illness, accounting for 10% to 15% of all occupational diseases.
This highlights the importance of developing rapid and sensitive methods for hazard identification of chemical sensitizers.
The murine local lymph node assay (LLNA) was developed and validated for the identification of low molecular weight sensitizing chemicals.
It provides several benefits over other tests for sensitization because it provides a quantitative endpoint, dose-responsive data, and allows for prediction of potency.
However, there are also several concerns with this assay including: levels of false positive responses, variability due to vehicle, and predictivity.
This report serves as a concise review which briefly summarizes the progress, advances and limitations of the assay over the last decade.
American Psychological Association (APA)
Anderson, Stacey E.& Siegel, Paul D.& Meade, B. Jean. 2011. The LLNA : A Brief Review of Recent Advances and Limitations. Journal of Allergy،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-471079
Modern Language Association (MLA)
Anderson, Stacey E.…[et al.]. The LLNA : A Brief Review of Recent Advances and Limitations. Journal of Allergy No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-471079
American Medical Association (AMA)
Anderson, Stacey E.& Siegel, Paul D.& Meade, B. Jean. The LLNA : A Brief Review of Recent Advances and Limitations. Journal of Allergy. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-471079
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471079