Unique Properties of Hepatocarcinogenesis-Resistant DRH Rat Hepatocytes Linked or Not Linked to the Drh1 Locus on Rat Chromosome 1
Joint Authors
Ogawa, Katsuhiro
Hashimoto, Norikazu
Tanaka, Hiroki
Yamamoto, Masahiro
Miyakoshi, Masaaki
Source
International Journal of Hepatology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Hepatocarcinogenesis-resistant DRH rats exhibit few and small preneoplastic hepatocytic lesions during hepatocarcinogenesis, of which traits have been assigned to two major chromosomal regions, Drh1 and Drh2.
In this study, hepatocytes from DRH.F344-Drh1, a congenic strain in which the Drh1 chromosomal region was replaced with that of F344 rats, were compared to hepatocytes from Donryu (original strain), DRH, and F344 rats.
Although DRH hepatocytes exhibited low proliferation and p38 dephosphorylation after lead nitrate (LN) treatment despite cytokine and Cox2 activation, DRH.F344-Drh1 hepatocytes exhibited high responses, as did Donryu and F344 hepatocytes.
Moreover, although DRH hepatocytes were resistant to hepatotoxins, DRH.F344-Drh1 hepatocytes were as sensitive to hepatotoxins as Donryu and F344 hepatocytes.
However, DRH.F344-Drh1 hepatocytes like DRH hepatocytes proliferated at lower rates in vitro and contained smaller nuclei than Donryu and F344 hepatocytes.
Thus, low responses to LN and resistance to hepatotoxins in DRH hepatocytes were linked to the Drh1 locus, while low proliferation in vitro and small nuclear size were not linked to the Drh1 locus.
American Psychological Association (APA)
Hashimoto, Norikazu& Yamamoto, Masahiro& Miyakoshi, Masaaki& Tanaka, Hiroki& Ogawa, Katsuhiro. 2011. Unique Properties of Hepatocarcinogenesis-Resistant DRH Rat Hepatocytes Linked or Not Linked to the Drh1 Locus on Rat Chromosome 1. International Journal of Hepatology،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-471091
Modern Language Association (MLA)
Hashimoto, Norikazu…[et al.]. Unique Properties of Hepatocarcinogenesis-Resistant DRH Rat Hepatocytes Linked or Not Linked to the Drh1 Locus on Rat Chromosome 1. International Journal of Hepatology No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-471091
American Medical Association (AMA)
Hashimoto, Norikazu& Yamamoto, Masahiro& Miyakoshi, Masaaki& Tanaka, Hiroki& Ogawa, Katsuhiro. Unique Properties of Hepatocarcinogenesis-Resistant DRH Rat Hepatocytes Linked or Not Linked to the Drh1 Locus on Rat Chromosome 1. International Journal of Hepatology. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-471091
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471091