The Discovery of Novel Selective D1 Dopaminergic Agonists : A-68930, A-77636, A-86929, and ABT-413
Author
Source
International Journal of Medicinal Chemistry
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The novel selective D1 dopaminergic full agonists A-68930, A-77636 were discovered by the synthesis of molecules to probe the bioactive conformation of the partial agonist SKF-38393, by the use of this information to add D1 affinity and selectivity to a screening hit, and by traditional medicinal chemistry exploration of structure-activity relationships.
The subsequent design of A-86929 and ABT-413 capitalized on these results, recently disclosed agonists, and traditional medicinal chemistry.
American Psychological Association (APA)
Martin, Yvonne Connolly. 2011. The Discovery of Novel Selective D1 Dopaminergic Agonists : A-68930, A-77636, A-86929, and ABT-413. International Journal of Medicinal Chemistry،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-471099
Modern Language Association (MLA)
Martin, Yvonne Connolly. The Discovery of Novel Selective D1 Dopaminergic Agonists : A-68930, A-77636, A-86929, and ABT-413. International Journal of Medicinal Chemistry No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-471099
American Medical Association (AMA)
Martin, Yvonne Connolly. The Discovery of Novel Selective D1 Dopaminergic Agonists : A-68930, A-77636, A-86929, and ABT-413. International Journal of Medicinal Chemistry. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-471099
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471099