Biodegradable Polymers Induce CD54 on THP-1 Cells in Skin Sensitization Test
Joint Authors
Kato, Reiko
Jung, Yeon Suk
Tsuchiya, Toshie
Source
International Journal of Biomaterials
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-02
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Currently, nonanimal methods of skin sensitization testing for various chemicals, biodegradable polymers, and biomaterials are being developed in the hope of eliminating the use of animals.
The human cell line activation test (h-CLAT) is a skin sensitization assessment that mimics the functions of dendritic cells (DCs).
DCs are specialized antigen-presenting cells, and they interact with T cells and B cells to initiate immune responses.
Phenotypic changes in DCs, such as the production of CD86 and CD54 and internalization of MHC class II molecules, have become focal points of the skin sensitization test.
In this study, we used h-CLAT to assess the effects of biodegradable polymers.
The results showed that several biodegradable polymers increased the expression of CD54, and the relative skin sensitizing abilities of biodegradable polymers were PLLG (75 : 25) < PLLC (40 : 60) < PLGA (50 : 50) < PCG (50 : 50).
These results may contribute to the creation of new guidelines for the use of biodegradable polymers in scaffolds or allergenic hazards.
American Psychological Association (APA)
Jung, Yeon Suk& Kato, Reiko& Tsuchiya, Toshie. 2011. Biodegradable Polymers Induce CD54 on THP-1 Cells in Skin Sensitization Test. International Journal of Biomaterials،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-471103
Modern Language Association (MLA)
Jung, Yeon Suk…[et al.]. Biodegradable Polymers Induce CD54 on THP-1 Cells in Skin Sensitization Test. International Journal of Biomaterials No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-471103
American Medical Association (AMA)
Jung, Yeon Suk& Kato, Reiko& Tsuchiya, Toshie. Biodegradable Polymers Induce CD54 on THP-1 Cells in Skin Sensitization Test. International Journal of Biomaterials. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-471103
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471103