Curcumin Pretreatment Prevents Potassium Dichromate-Induced Hepatotoxicity, Oxidative Stress, Decreased Respiratory Complex I Activity, and Membrane Permeability Transition Pore Opening
Joint Authors
Zazueta, Cecilia
Zatarain-Barrón, Zyanya Lucía
Vega-García, Claudia Cecilia
Tapia, Edilia
Hernández-Pando, Rogelio
Pedraza-Chaverri, José
García-Niño, Wylly Ramsés
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-17
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Curcumin is a polyphenol derived from turmeric with recognized antioxidant properties.
Hexavalent chromium is an environmental toxic and carcinogen compound that induces oxidative stress.
The objective of this study was to evaluate the potential protective effect of curcumin on the hepatic damage generated by potassium dichromate (K2Cr2O7) in rats.
Animals were pretreated daily by 9-10 days with curcumin (400 mg/kg b.w.) before the injection of a single intraperitoneal of K2Cr2O7 (15 mg/kg b.w.).
Groups of animals were sacrificed 24 and 48 h later.
K2Cr2O7-induced damage to the liver was evident by histological alterations and increase in the liver weight and in the activity of alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, and alkaline phosphatase in plasma.
In addition, K2Cr2O7 induced oxidative damage in liver and isolated mitochondria, which was evident by the increase in the content of malondialdehyde and protein carbonyl and decrease in the glutathione content and in the activity of several antioxidant enzymes.
Moreover, K2Cr2O7 induced decrease in mitochondrial oxygen consumption, in the activity of respiratory complex I, and permeability transition pore opening.
All the above-mentioned alterations were prevented by curcumin pretreatment.
The beneficial effects of curcumin against K2Cr2O7-induced liver oxidative damage were associated with prevention of mitochondrial dysfunction.
American Psychological Association (APA)
García-Niño, Wylly Ramsés& Tapia, Edilia& Zazueta, Cecilia& Zatarain-Barrón, Zyanya Lucía& Hernández-Pando, Rogelio& Vega-García, Claudia Cecilia…[et al.]. 2013. Curcumin Pretreatment Prevents Potassium Dichromate-Induced Hepatotoxicity, Oxidative Stress, Decreased Respiratory Complex I Activity, and Membrane Permeability Transition Pore Opening. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-19.
https://search.emarefa.net/detail/BIM-471110
Modern Language Association (MLA)
García-Niño, Wylly Ramsés…[et al.]. Curcumin Pretreatment Prevents Potassium Dichromate-Induced Hepatotoxicity, Oxidative Stress, Decreased Respiratory Complex I Activity, and Membrane Permeability Transition Pore Opening. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-19.
https://search.emarefa.net/detail/BIM-471110
American Medical Association (AMA)
García-Niño, Wylly Ramsés& Tapia, Edilia& Zazueta, Cecilia& Zatarain-Barrón, Zyanya Lucía& Hernández-Pando, Rogelio& Vega-García, Claudia Cecilia…[et al.]. Curcumin Pretreatment Prevents Potassium Dichromate-Induced Hepatotoxicity, Oxidative Stress, Decreased Respiratory Complex I Activity, and Membrane Permeability Transition Pore Opening. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-19.
https://search.emarefa.net/detail/BIM-471110
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471110