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RNA-Mediated Gene Duplication and Retroposons : Retrogenes, LINEs, SINEs, and Sequence Specificity
Author
Source
International Journal of Evolutionary Biology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-01
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
A substantial number of “retrogenes” that are derived from the mRNA of various intron-containing genes have been reported.
A class of mammalian retroposons, long interspersed element-1 (LINE1, L1), has been shown to be involved in the reverse transcription of retrogenes (or processed pseudogenes) and non-autonomous short interspersed elements (SINEs).
The 3′-end sequences of various SINEs originated from a corresponding LINE.
As the 3′-untranslated regions of several LINEs are essential for retroposition, these LINEs presumably require “stringent” recognition of the 3′-end sequence of the RNA template.
However, the 3′-ends of mammalian L1s do not exhibit any similarity to SINEs, except for the presence of 3′-poly(A) repeats.
Since the 3′-poly(A) repeats of L1 and Alu SINE are critical for their retroposition, L1 probably recognizes the poly(A) repeats, thereby mobilizing not only Alu SINE but also cytosolic mRNA.
Many flowering plants only harbor L1-clade LINEs and a significant number of SINEs with poly(A) repeats, but no homology to the LINEs.
Moreover, processed pseudogenes have also been found in flowering plants.
I propose that the ancestral L1-clade LINE in the common ancestor of green plants may have recognized a specific RNA template, with stringent recognition then becoming relaxed during the course of plant evolution.
American Psychological Association (APA)
Ohshima, Kazuhiko. 2013. RNA-Mediated Gene Duplication and Retroposons : Retrogenes, LINEs, SINEs, and Sequence Specificity. International Journal of Evolutionary Biology،Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-471116
Modern Language Association (MLA)
Ohshima, Kazuhiko. RNA-Mediated Gene Duplication and Retroposons : Retrogenes, LINEs, SINEs, and Sequence Specificity. International Journal of Evolutionary Biology No. 2013 (2013), pp.1-16.
https://search.emarefa.net/detail/BIM-471116
American Medical Association (AMA)
Ohshima, Kazuhiko. RNA-Mediated Gene Duplication and Retroposons : Retrogenes, LINEs, SINEs, and Sequence Specificity. International Journal of Evolutionary Biology. 2013. Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-471116
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471116