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Possible Role of Platelet GluR1 Receptors in Comorbid Depression and Cardiovascular Disease
Author
Source
Cardiovascular Psychiatry and Neurology
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-08-16
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
The exact nature of the comorbidity between cardiovascular disease (CVD) and major depressive disorder (MDD) is poorly understood.
The proposed mechanisms include various biochemical and molecular pathways as well as health behaviors such as physical inactivity.
One possible link between MDD and CVD is increased platelet activity and blood viscosity.
Recently, it was discovered that platelets express functional subtype of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, for example, glutamate receptor 1 (GluR1).
Here, I propose that this type of AMPA receptor could play a role in comorbid MDD and CVD, and antidepressants may interfere with platelet activation via direct or indirect effects on platelet GluR1 phosphorylation.
Testing this hypothesis could provide a novel view on the pathobiological mechanisms of comorbid MDD and CVD.
With respect to the recently discovered role of AMPA receptors in regulating platelet activation and thrombosis, it appears that the information about the putative effects of psychoactive AMPA-modifying drugs on platelet AMPA receptors would be critical in evaluating the putative effects of such drugs on CVD.
American Psychological Association (APA)
Chen, Hu. 2009. Possible Role of Platelet GluR1 Receptors in Comorbid Depression and Cardiovascular Disease. Cardiovascular Psychiatry and Neurology،Vol. 2009, no. 2009, pp.1-3.
https://search.emarefa.net/detail/BIM-471117
Modern Language Association (MLA)
Chen, Hu. Possible Role of Platelet GluR1 Receptors in Comorbid Depression and Cardiovascular Disease. Cardiovascular Psychiatry and Neurology No. 2009 (2009), pp.1-3.
https://search.emarefa.net/detail/BIM-471117
American Medical Association (AMA)
Chen, Hu. Possible Role of Platelet GluR1 Receptors in Comorbid Depression and Cardiovascular Disease. Cardiovascular Psychiatry and Neurology. 2009. Vol. 2009, no. 2009, pp.1-3.
https://search.emarefa.net/detail/BIM-471117
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471117