Factor VII Activating Protease Polymorphism (G534E) Is Associated with Increased Risk for Stroke and Mortality
Joint Authors
de Craen, Anton J. M.
Ikram, M. Arfan
Pons, Douwe
Jukema, Jan Wouter
Doevendans, Pieter A. F. M.
Zwinderman, Aeilko H.
Tio, René A.
Westendorp, Rudi G. J.
de Winter, Robbert J.
Trompet, Stella
Kanse, Sandip M.
Slagboom, P. Eline
Verschuren, Jeffrey J. W.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Introduction.
The FSAP-Marburg I polymorphism (1704G > A), which reduces FSAP activity, is associated with late complications of carotid stenosis in humans.
Therefore, this study examines the influence of the Marburg I polymorphism and the closely linked Marburg II polymorphism (1280G > C) on various cardiovascular outcomes in two large independent study populations.
Methods.
The two Marburg polymorphisms in the HABP2 gene encoding FSAP were genotyped in a large population of elderly patients at risk for vascular disease (the PROSPER-study, n=5804) and in a study population treated with a percutaneous coronary intervention (the GENDER-study, n=3104).
Results.
In the PROSPER study, the Marburg I polymorphism was associated with an increased risk of clinical stroke (HR: 1.60, 95% CI: 1.13–2.28) and all-cause mortality (HR: 1.33, 95% CI: 1.04–1.71).
In the GENDER study carriers of this variant seemed at lower risk of developing restenosis (HR: 0.59, 95% CI: 0.34–1.01).
The Marburg II polymorphism showed similar but weaker results.
Conclusion.
The increase in stroke risk in Marburg I carriers could be due to differential effects on smooth muscle cells and on matrix metalloproteinases, thereby influencing plaque stability.
The possible protective effect on restenosis could be the result of reduced activation of zymogens, which are involved in hemostasis and matrix remodeling.
American Psychological Association (APA)
Trompet, Stella& Pons, Douwe& Kanse, Sandip M.& de Craen, Anton J. M.& Ikram, M. Arfan& Verschuren, Jeffrey J. W.…[et al.]. 2011. Factor VII Activating Protease Polymorphism (G534E) Is Associated with Increased Risk for Stroke and Mortality. Stroke Research and Treatment،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-471119
Modern Language Association (MLA)
Trompet, Stella…[et al.]. Factor VII Activating Protease Polymorphism (G534E) Is Associated with Increased Risk for Stroke and Mortality. Stroke Research and Treatment No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-471119
American Medical Association (AMA)
Trompet, Stella& Pons, Douwe& Kanse, Sandip M.& de Craen, Anton J. M.& Ikram, M. Arfan& Verschuren, Jeffrey J. W.…[et al.]. Factor VII Activating Protease Polymorphism (G534E) Is Associated with Increased Risk for Stroke and Mortality. Stroke Research and Treatment. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-471119
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471119