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Protein-Protein Interaction Changes in an Archaeal Light-Signal Transduction
Joint Authors
Sudo, Yuki
Kandori, Hideki
Furutani, Yuji
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-29
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Negative phototaxis in Natronomonas pharaonis is initiated by transient interaction changes between photoreceptor and transducer.
pharaonis phoborhodopsin (ppR; also called pharaonis sensory rhodopsin II, psR-II) and the cognate transducer protein, pHtrII, form a tight 2 : 2 complex in the unphotolyzed state, and the interaction is somehow altered during the photocycle of ppR.
We have studied the signal transduction mechanism in the ppR/pHtrII system by means of low-temperature Fourier-transform infrared (FTIR) spectroscopy.
In the paper, spectral comparison in the absence and presence of pHtrII provided fruitful information in atomic details, where vibrational bands were identified by the use of isotope-labeling and site-directed mutagenesis.
From these studies, we established the two pathways of light-signal conversion from the receptor to the transducer; (i) from Lys205 (retinal) of ppR to Asn74 of pHtrII through Thr204 and Tyr199, and (ii) from Lys205 of ppR to the cytoplasmic loop region of pHtrII that links Gly83.
American Psychological Association (APA)
Kandori, Hideki& Sudo, Yuki& Furutani, Yuji. 2010. Protein-Protein Interaction Changes in an Archaeal Light-Signal Transduction. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-14.
https://search.emarefa.net/detail/BIM-471120
Modern Language Association (MLA)
Kandori, Hideki…[et al.]. Protein-Protein Interaction Changes in an Archaeal Light-Signal Transduction. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-14.
https://search.emarefa.net/detail/BIM-471120
American Medical Association (AMA)
Kandori, Hideki& Sudo, Yuki& Furutani, Yuji. Protein-Protein Interaction Changes in an Archaeal Light-Signal Transduction. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-14.
https://search.emarefa.net/detail/BIM-471120
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471120