Controversies on Rituximab Therapy in Sjögren Syndrome-Associated Lymphoproliferation
Joint Authors
Salvin, Sara
Maset, Marta
Fabris, Martina
De Vita, Salvatore
De Marchi, Ginevra
Quartuccio, Luca
Source
International Journal of Rheumatology
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-01-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Sjögren's syndrome (SS) is a systemic autoimmune disease characterized by chronic inflammation of salivary and lachrymal glands, and frequently accompanied by systemic symptoms.
A subgroup of SS patients develops malignant B cell non-Hodgkin's lymphoma (NHL), usually of the mucosa-associated lymphoid tissue (MALT) type and very often located in the major salivary glands.
Currently, there is a lack of evidence-based intervention therapy which may influence SS-related chronic inflammation and lymphoproliferation.
B cells are involved in the pathogenesis of SS, and B cell downregulation may lead to a decrease of disease activity.
Rituximab (RTX), a chimeric monoclonal antibody targeting the CD20 antigen on the B cell surface, has been successfully investigated in other autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematosus, ANCA-associated vasculitis, and mixed cryoglobulinemic syndrome.
Preliminary experiences of RTX therapy in SS patients with or without a lymphoproliferative disorder suggest that SS patients with more residual exocrine gland function might better benefit from RTX.
Efficacy of RTX in SS-associated B-cell lymphoma, mainly in low-grade salivary gland lymphomas, remains an open issue.
American Psychological Association (APA)
Quartuccio, Luca& Fabris, Martina& Salvin, Sara& Maset, Marta& De Marchi, Ginevra& De Vita, Salvatore. 2010. Controversies on Rituximab Therapy in Sjögren Syndrome-Associated Lymphoproliferation. International Journal of Rheumatology،Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-471141
Modern Language Association (MLA)
Quartuccio, Luca…[et al.]. Controversies on Rituximab Therapy in Sjögren Syndrome-Associated Lymphoproliferation. International Journal of Rheumatology No. 2009 (2009), pp.1-8.
https://search.emarefa.net/detail/BIM-471141
American Medical Association (AMA)
Quartuccio, Luca& Fabris, Martina& Salvin, Sara& Maset, Marta& De Marchi, Ginevra& De Vita, Salvatore. Controversies on Rituximab Therapy in Sjögren Syndrome-Associated Lymphoproliferation. International Journal of Rheumatology. 2010. Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-471141
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471141