Intravenous Sphingosylphosphorylcholine Protects Ischemic and Postischemic Myocardial Tissue in a Mouse Model of Myocardial IschemiaReperfusion Injury
Joint Authors
Johanning, Kai
Herrgott, Ilka
Hildebrand, Reinhard
Müller, Frank Ulrich
Herzog, Christine
Winterhalter, Michael
Schmitz, Martina
Echtermeyer, Frank
Larmann, Jan
Theilmeier, Gregor
Levkau, Bodo
Chun, Jerold
Mersmann, Jan
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
HDL, through sphingosine-1-phosphate (S1P), exerts direct cardioprotective effects on ischemic myocardium.
It remains unclear whether other HDL-associated sphingophospholipids have similar effects.
We therefore examined if HDL-associated sphingosylphosphorylcholine (SPC) reduces infarct size in a mouse model of transient myocardial ischemia/reperfusion.
Intravenously administered SPC dose-dependently reduced infarct size after 30 minutes of myocardial ischemia and 24 hours reperfusion compared to controls.
Infarct size was also reduced by postischemic, therapeutical administration of SPC.
Immunohistochemistry revealed reduced polymorphonuclear neutrophil recruitment to the infarcted area after SPC treatment, and apoptosis was attenuated as measured by TUNEL.
In vitro, SPC inhibited leukocyte adhesion to TNFα-activated endothelial cells and protected rat neonatal cardiomyocytes from apoptosis.
S1P3 was identified as the lysophospholipid receptor mediating the cardioprotection by SPC, since its effect was completely absent in S1P3-deficient mice.
We conclude that HDL-associated SPC directly protects against myocardial reperfusion injury in vivo via the S1P3 receptor.
American Psychological Association (APA)
Herzog, Christine& Schmitz, Martina& Levkau, Bodo& Herrgott, Ilka& Mersmann, Jan& Larmann, Jan…[et al.]. 2011. Intravenous Sphingosylphosphorylcholine Protects Ischemic and Postischemic Myocardial Tissue in a Mouse Model of Myocardial IschemiaReperfusion Injury. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-471167
Modern Language Association (MLA)
Herzog, Christine…[et al.]. Intravenous Sphingosylphosphorylcholine Protects Ischemic and Postischemic Myocardial Tissue in a Mouse Model of Myocardial IschemiaReperfusion Injury. Mediators of Inflammation No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-471167
American Medical Association (AMA)
Herzog, Christine& Schmitz, Martina& Levkau, Bodo& Herrgott, Ilka& Mersmann, Jan& Larmann, Jan…[et al.]. Intravenous Sphingosylphosphorylcholine Protects Ischemic and Postischemic Myocardial Tissue in a Mouse Model of Myocardial IschemiaReperfusion Injury. Mediators of Inflammation. 2011. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-471167
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471167