How Sleep Activates Epileptic Networks?
Author
Source
Epilepsy Research and Treatment
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-12
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Background.
The relationship between sleep and epilepsy has been long ago studied, and several excellent reviews are available.
However, recent development in sleep research, the network concept in epilepsy, and the recognition of high frequency oscillations in epilepsy and more new results may put this matter in a new light.
Aim.
The review address the multifold interrelationships between sleep and epilepsy networks and with networks of cognitive functions.
Material and Methods.
The work is a conceptual update of the available clinical data and relevant studies.
Results and Conclusions.
Studies exploring dynamic microstructure of sleep have found important gating mechanisms for epileptic activation.
As a general rule interictal epileptic manifestations seem to be linked to the slow oscillations of sleep and especially to the reactive delta bouts characterized by A1 subtype in the CAP system.
Important link between epilepsy and sleep is the interference of epileptiform discharges with the plastic functions in NREM sleep.
This is the main reason of cognitive impairment in different forms of early epileptic encephalopathies affecting the brain in a special developmental window.
The impairment of cognitive functions via sleep is present especially in epileptic networks involving the thalamocortical system and the hippocampocortical memory encoding system.
American Psychological Association (APA)
Halász, Péter. 2013. How Sleep Activates Epileptic Networks?. Epilepsy Research and Treatment،Vol. 2013, no. 2013, pp.1-19.
https://search.emarefa.net/detail/BIM-471197
Modern Language Association (MLA)
Halász, Péter. How Sleep Activates Epileptic Networks?. Epilepsy Research and Treatment No. 2013 (2013), pp.1-19.
https://search.emarefa.net/detail/BIM-471197
American Medical Association (AMA)
Halász, Péter. How Sleep Activates Epileptic Networks?. Epilepsy Research and Treatment. 2013. Vol. 2013, no. 2013, pp.1-19.
https://search.emarefa.net/detail/BIM-471197
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471197