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Platelet Aggregation Pathway Network-Based Approach for Evaluating Compounds Efficacy
Joint Authors
Hou, Tingjun
Chen, Lirong
Li, Youyong
Xu, Xiaojie
Yuan, Gu
Li, Qian
Gu, Jiangyong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Traditional Chinese medicines (TCMs) contain a large quantity of compounds with multiple biological activities.
By using multitargets docking and network analysis in the context of pathway network of platelet aggregation, we proposed network efficiency and network flux model to screen molecules which can be used as drugs for antiplatelet aggregation.
Compared with traditional single-target screening methods, network efficiency and network flux take into account the influences which compounds exert on the whole pathway network.
The activities of antiplatelet aggregation of 19 active ingredients separated from TCM and 14 nonglycoside compounds predicated from network efficiency and network flux model show good agreement with experimental results (correlation coefficient = 0.73 and 0.90, resp.).
This model can be used to evaluate the potential bioactive compounds and thus bridges the gap between computation and clinical indicator.
American Psychological Association (APA)
Gu, Jiangyong& Li, Qian& Chen, Lirong& Li, Youyong& Hou, Tingjun& Yuan, Gu…[et al.]. 2013. Platelet Aggregation Pathway Network-Based Approach for Evaluating Compounds Efficacy. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-471198
Modern Language Association (MLA)
Gu, Jiangyong…[et al.]. Platelet Aggregation Pathway Network-Based Approach for Evaluating Compounds Efficacy. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-471198
American Medical Association (AMA)
Gu, Jiangyong& Li, Qian& Chen, Lirong& Li, Youyong& Hou, Tingjun& Yuan, Gu…[et al.]. Platelet Aggregation Pathway Network-Based Approach for Evaluating Compounds Efficacy. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-471198
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471198