Aspartoacylase Deficiency in the White Matter of Human Immunodeficiency Virus Encephalitis : Novel Mechanism in Axonal Damage
Joint Authors
Rajasankar, Srinivasagam
Surendran, Sankar
Source
Pathology Research International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-06
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Aspartoacylase/aminoacylase II (ASPA/ACY II) is mainly synthesized in oligodendrocytes to contribute in myelin synthesis.
Although axonal damage is seen in the brain with human immunodeficiency virus encephalitis (HIVE), ASPA contribution in the pathology is not known.
Immunostaining study showed that ASPA protein is reduced in the white matter of patients with HIVE compared to the control.
Western blot study further confirmed ASPA deficiency in the HIVE brain compared to the control.
This paper suggests that HIVE condition affects ASPA to contribute in myelin loss/axonal damage seen in the disease.
American Psychological Association (APA)
Surendran, Sankar& Rajasankar, Srinivasagam. 2011. Aspartoacylase Deficiency in the White Matter of Human Immunodeficiency Virus Encephalitis : Novel Mechanism in Axonal Damage. Pathology Research International،Vol. 2011, no. 2011, pp.1-3.
https://search.emarefa.net/detail/BIM-471242
Modern Language Association (MLA)
Surendran, Sankar& Rajasankar, Srinivasagam. Aspartoacylase Deficiency in the White Matter of Human Immunodeficiency Virus Encephalitis : Novel Mechanism in Axonal Damage. Pathology Research International No. 2011 (2011), pp.1-3.
https://search.emarefa.net/detail/BIM-471242
American Medical Association (AMA)
Surendran, Sankar& Rajasankar, Srinivasagam. Aspartoacylase Deficiency in the White Matter of Human Immunodeficiency Virus Encephalitis : Novel Mechanism in Axonal Damage. Pathology Research International. 2011. Vol. 2011, no. 2011, pp.1-3.
https://search.emarefa.net/detail/BIM-471242
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471242