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HIC-5 : A Mobile Molecular Scaffold Regulating the Anchorage Dependence of Cell Growth
Joint Authors
Nose, Kiyoshi
Shibanuma, Motoko
Mori, Kazunori
Source
International Journal of Cell Biology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
HIC-5 is a multidomain LIM protein homologous to paxillin that serves as a molecular scaffold at focal adhesions and in the nucleus.
It forms mobile molecular units with LIM-only proteins, PINCH, and CRP2 and translocates in and out of the nucleus via a nuclear export signal (NES).
Of note, NES of HIC-5 is distinctive in its sensitivity to the cellular redox state.
Recently, the mobile units of HIC-5 have been suggested to be involved in the regulation of the anchorage dependence of cell growth.
On loss of adhesion, an increase in reactive oxygen species in the cells modifies NES and stops shuttling, which leads to cell-cycle control.
More specifically, the system circumvents nuclear localization of cyclin D1 and transactivates p21Cip1 in detached cells, thereby avoiding anchorage-independent cell growth.
Thus, the HIC-5-LIM only protein complex has emerged as a fail-safe system for regulating the anchorage dependence of cell growth.
American Psychological Association (APA)
Shibanuma, Motoko& Mori, Kazunori& Nose, Kiyoshi. 2011. HIC-5 : A Mobile Molecular Scaffold Regulating the Anchorage Dependence of Cell Growth. International Journal of Cell Biology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-471253
Modern Language Association (MLA)
Shibanuma, Motoko…[et al.]. HIC-5 : A Mobile Molecular Scaffold Regulating the Anchorage Dependence of Cell Growth. International Journal of Cell Biology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-471253
American Medical Association (AMA)
Shibanuma, Motoko& Mori, Kazunori& Nose, Kiyoshi. HIC-5 : A Mobile Molecular Scaffold Regulating the Anchorage Dependence of Cell Growth. International Journal of Cell Biology. 2011. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-471253
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471253