Circulating Tumor Cell Analysis : Technical and Statistical Considerations for Application to the Clinic
Joint Authors
Keeney, Michael
Allan, Alison L.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-12-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Solid cancers are a leading cause of death worldwide, primarily due to the failure of effective clinical detection and treatment of metastatic disease in distant sites.
There is growing evidence that the presence of circulating tumor cells (CTCs) in the blood of cancer patients may be an important indicator of the potential for metastatic disease and poor prognosis.
Technological advances have now facilitated the enumeration and characterization of CTCs using methods such as PCR, flow cytometry, image-based immunologic approaches, immunomagnetic techniques, and microchip technology.
However, the rare nature of these cells requires that very sensitive and robust detection/enumeration methods be developed and validated in order to implement CTC analysis for widespread use in the clinic.
This review will focus on the important technical and statistical considerations that must be taken into account when designing and implementing CTC assays, as well as the subsequent interpretation of these results for the purposes of clinical decision making.
American Psychological Association (APA)
Allan, Alison L.& Keeney, Michael. 2009. Circulating Tumor Cell Analysis : Technical and Statistical Considerations for Application to the Clinic. Journal of Oncology،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-471265
Modern Language Association (MLA)
Allan, Alison L.& Keeney, Michael. Circulating Tumor Cell Analysis : Technical and Statistical Considerations for Application to the Clinic. Journal of Oncology No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-471265
American Medical Association (AMA)
Allan, Alison L.& Keeney, Michael. Circulating Tumor Cell Analysis : Technical and Statistical Considerations for Application to the Clinic. Journal of Oncology. 2009. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-471265
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471265