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Effect of Nonviral Plasmid Delivered Basic Fibroblast Growth Factor and Low Intensity Pulsed Ultrasound on Mandibular Condylar Growth : A Preliminary Study
Joint Authors
Kaur, Harmanpreet
Uludağ, Hasan
El-Bialy, Tarek
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
Basic fibroblast growth factor (bFGF) is an important regulator of tissue growth.
Previous studies have shown that low intensity pulsed ultrasound (LIPUS) stimulates bone growth.
The objective of this study was to evaluate the possible synergetic effect of LIPUS and local injection of nonviral bFGF plasmid DNA (pDNA) on mandibular growth in rats.
Design.
Groups were control, blank pDNA, bFGF pDNA, LIPUS, and bFGF pDNA + LIPUS.
Treatments were performed for 28 days.
Significant increase was observed in mandibular height and condylar length in LIPUS groups.
MicroCT analysis showed significant increase in bone volume fraction in bFGF pDNA + LIPUS group.
Histomorphometric analysis showed increased cell count and condylar proliferative and hypertrophic layers widths in bFGF pDNA group.
Results.
Current study showed increased mandibular condylar growth in either bFGF pDNA or LIPUS groups compared to the combined group that showed only increased bone volume fraction.
Conclusion.
It appears that there is an additive effect of bFGF + LIPUS on the mandibular growth.
American Psychological Association (APA)
Kaur, Harmanpreet& Uludağ, Hasan& El-Bialy, Tarek. 2014. Effect of Nonviral Plasmid Delivered Basic Fibroblast Growth Factor and Low Intensity Pulsed Ultrasound on Mandibular Condylar Growth : A Preliminary Study. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-471302
Modern Language Association (MLA)
Kaur, Harmanpreet…[et al.]. Effect of Nonviral Plasmid Delivered Basic Fibroblast Growth Factor and Low Intensity Pulsed Ultrasound on Mandibular Condylar Growth : A Preliminary Study. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-471302
American Medical Association (AMA)
Kaur, Harmanpreet& Uludağ, Hasan& El-Bialy, Tarek. Effect of Nonviral Plasmid Delivered Basic Fibroblast Growth Factor and Low Intensity Pulsed Ultrasound on Mandibular Condylar Growth : A Preliminary Study. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-471302
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471302