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Serum Immunoglobulin Free Light Chain Assessment in IgG4-Related Disease
Joint Authors
Grados, Aurélie
Aucouturier, Pierre
Terrier, Benjamin
Costedoat-Chalumeau, Nathalie
Boucraut, José
Harle, Jean-Robert
Rigolet, Aude
Ebbo, Mikael
Ghillani-Dalbin, Pascale
Saadoun, David
Schleinitz, Nicolas
Vély, Frédéric
Source
International Journal of Rheumatology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-26
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Immunoglobulin free light chains are produced in excess during normal antibody synthesis.
Their evaluation is commonly used in case of a monoclonal gammopathy.
In polyclonal hypergammaglobulinemia related to the Sjögren syndrome or systemic lupus, erythematosus serum free light chain levels are increased and could correlate with disease activity.
We show here that the κ (P<0.0001) and λ (P=0.0003) free light chains and the κ : λ ratio (P=0.0049) are increased in sixteen patients with IgG4-related disease when compared to healthy controls.
The increase of κ and λ free light chains probably reflects the marked polyclonal B cell activation of the disease.
We could not assess in this small cohort of patients a significative correlation of serum free light chain levels and disease activity or extension.
American Psychological Association (APA)
Grados, Aurélie& Ebbo, Mikael& Boucraut, José& Vély, Frédéric& Aucouturier, Pierre& Rigolet, Aude…[et al.]. 2013. Serum Immunoglobulin Free Light Chain Assessment in IgG4-Related Disease. International Journal of Rheumatology،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-471307
Modern Language Association (MLA)
Grados, Aurélie…[et al.]. Serum Immunoglobulin Free Light Chain Assessment in IgG4-Related Disease. International Journal of Rheumatology No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-471307
American Medical Association (AMA)
Grados, Aurélie& Ebbo, Mikael& Boucraut, José& Vély, Frédéric& Aucouturier, Pierre& Rigolet, Aude…[et al.]. Serum Immunoglobulin Free Light Chain Assessment in IgG4-Related Disease. International Journal of Rheumatology. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-471307
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471307