Hypoxia-Induced Oxidative Stress in Ischemic Retinopathy
Joint Authors
Li, Suk-Yee
Lo, Amy Cheuk Yin
Fu, Zhong Jie
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Oxidative stress plays a crucial role in the pathogenesis of retinal ischemia/hypoxia, a complication of ocular diseases such as diabetic retinopathy (DR) and retinopathy of prematurity (ROP).
Oxidative stress refers to the imbalance between the production of reactive oxygen species (ROS) and the ability to scavenge these ROS by endogenous antioxidative systems.
Free radicals and ROS are implicated in the irreversible damage to cell membrane, DNA, and other cellular structures by oxidizing lipids, proteins, and nucleic acids.
Anti-oxidants that can inhibit the oxidative processes can protect retinal cells from ischemic/hypoxic insults.
In particular, treatment using anti-oxidants such as vitamin E and lutein, inhibition of nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase) or related signaling pathways, and administration of catalase and superoxide dismutase (SOD) are possible therapeutic regimens for DR, ROP, and other retinal ischemic diseases.
The role of oxidative stress in the pathogenesis of DR and ROP as well as the underlying mechanisms involved in the hypoxia/ischemia-induced oxidative damage is discussed.
The information provided will be beneficial in understanding the underlying mechanisms involved in the pathogenesis of the diseases as well as in developing effective therapeutic interventions to treat oxidative stress-induced damages.
American Psychological Association (APA)
Li, Suk-Yee& Fu, Zhong Jie& Lo, Amy Cheuk Yin. 2012. Hypoxia-Induced Oxidative Stress in Ischemic Retinopathy. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-471309
Modern Language Association (MLA)
Li, Suk-Yee…[et al.]. Hypoxia-Induced Oxidative Stress in Ischemic Retinopathy. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-471309
American Medical Association (AMA)
Li, Suk-Yee& Fu, Zhong Jie& Lo, Amy Cheuk Yin. Hypoxia-Induced Oxidative Stress in Ischemic Retinopathy. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-471309
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471309