Protective Role of Black Tea Extract against Nonalcoholic Steatohepatitis-Induced Skeletal Dysfunction
Joint Authors
Ghosh, Aniruddha
Das, Asankur Sekhar
Maiti, Anasuya
Mitra, Chandan
Karmakar, Subhra
Choudhury, Monalisa
Majumdar, Sangita
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-23
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Aim.
This paper aimed to examine the chemoprotective actions of aqueous black tea extract (BTE) against nonalcoholic steatohepatitis- (NASH-) induced skeletal changes in rats.
Material.
Wistar rats (body wt.
155–175 g) of both sexes, aged 4–5 months, were randomly assigned to 3 groups; Group A (control), Group B (60% high-fat diet; HFD), and Group C (HFD + 2.5% BTE).
Methods.
Several urinary (calcium, phosphate, creatinine, and calcium-to-creatinine ratio) serum (alkaline phosphatase and serum tartrate-resistant acid phosphatase), and molecular markers of bone turnover (receptor activator of NF-κB ligand (RANKL), osteoprotegerin (OPG), and estrogen) were tested.
Also, several bone parameters (bone density, bone tensile strength, bone mineral content, and bone histology) and calcium homeostasis were checked.
Results.
Results indicated that HFD-induced alterations in urinary, serum, and bone parameters as well as calcium homeostasis, all could be significantly ameliorated by BTE supplementation.
Conclusion.
Results suggest a potential role of BTE as a protective agent against NASH-induced changes in bone metabolism in rats.
American Psychological Association (APA)
Karmakar, Subhra& Majumdar, Sangita& Maiti, Anasuya& Choudhury, Monalisa& Ghosh, Aniruddha& Das, Asankur Sekhar…[et al.]. 2011. Protective Role of Black Tea Extract against Nonalcoholic Steatohepatitis-Induced Skeletal Dysfunction. Journal of Osteoporosis،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-471317
Modern Language Association (MLA)
Karmakar, Subhra…[et al.]. Protective Role of Black Tea Extract against Nonalcoholic Steatohepatitis-Induced Skeletal Dysfunction. Journal of Osteoporosis No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-471317
American Medical Association (AMA)
Karmakar, Subhra& Majumdar, Sangita& Maiti, Anasuya& Choudhury, Monalisa& Ghosh, Aniruddha& Das, Asankur Sekhar…[et al.]. Protective Role of Black Tea Extract against Nonalcoholic Steatohepatitis-Induced Skeletal Dysfunction. Journal of Osteoporosis. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-471317
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471317