Is There a Role for Mammalian Target of Rapamycin Inhibition in Renal Failure due to Mesangioproliferative Nephrotic Syndrome?
Joint Authors
Raña, María Soledad
Trimarchi, Hernán
Pomeranz, Vanesa
Iriarte, Romina
Forrester, Mariano
Young, Pablo
Lombi, Fernando
Source
International Journal of Nephrology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-21
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Primary glomerulonephritis stands as the third most important cause of end-stage renal disease, suggesting that appropriate treatment may not be as effective as intended to be.
Moreover, proteinuria, the hallmark of glomerular damage and a prognostic marker of renal damage progression, is frequently resistant to thorough control.
In addition, proteinuria may be the common end pathway in which different pathogenetic mechanisms may converge.
This explains why immunosuppressive and nonimmunosuppressive approaches are partly not sufficient to halt disease progression.
One of the commonest causes of primary glomerulonephritis is mesangioproliferative glomerulonephritis.
Among the triggered intracellular pathways involved in mesangial cell proliferation, the mammalian target of rapamycin (mTOR) plays a critical role in cell growth, in turn regulated by many cytokines, disbalanced by the altered glomerulopathy itself.
However, when inhibition of mTOR was studied in rodents and in humans with primary glomerulonephritis the results were contradictory.
In light of these controversial data, we propose an explanation for these results, to dilucidate under which circumstances mTOR inhibition should be considered to treat glomerular proteinuria and finally to propose mTOR inhibitors to be prospectively assessed in clinical trials in patients with primary mesangioproliferative glomerulonephritis, for which a satisfactory standard immunosuppressive regimen is still pending.
American Psychological Association (APA)
Trimarchi, Hernán& Forrester, Mariano& Lombi, Fernando& Pomeranz, Vanesa& Iriarte, Romina& Raña, María Soledad…[et al.]. 2012. Is There a Role for Mammalian Target of Rapamycin Inhibition in Renal Failure due to Mesangioproliferative Nephrotic Syndrome?. International Journal of Nephrology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-471343
Modern Language Association (MLA)
Trimarchi, Hernán…[et al.]. Is There a Role for Mammalian Target of Rapamycin Inhibition in Renal Failure due to Mesangioproliferative Nephrotic Syndrome?. International Journal of Nephrology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-471343
American Medical Association (AMA)
Trimarchi, Hernán& Forrester, Mariano& Lombi, Fernando& Pomeranz, Vanesa& Iriarte, Romina& Raña, María Soledad…[et al.]. Is There a Role for Mammalian Target of Rapamycin Inhibition in Renal Failure due to Mesangioproliferative Nephrotic Syndrome?. International Journal of Nephrology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-471343
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471343