The Reaction of Cyclopentanone with Cyanomethylene Reagents : Novel Synthesis of Pyrazole, Thiophene, and Pyridazine Derivatives
Joint Authors
Samir, Eman M.
Wardakhan, Wagnat W.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-06
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The reaction of cyclopentanone with either malononitrile or ethyl cyanoacetate gave the corresponding condensated products.
The latter underwent some heterocyclic reactions to give new pyrazole, thiophene, and pyridazine derivatives.
The antitumor evaluation of the newly synthesized products against the three cancer cells, namely, breast adenocarcinoma (MCF-7), nonsmall cell lung cancer (NCI-H460), and CNS cancer (SF-268) showed that some of them have high inhibitory effect towards three cell lines which is higher than the standard.
American Psychological Association (APA)
Wardakhan, Wagnat W.& Samir, Eman M.. 2013. The Reaction of Cyclopentanone with Cyanomethylene Reagents : Novel Synthesis of Pyrazole, Thiophene, and Pyridazine Derivatives. Journal of Chemistry،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-471350
Modern Language Association (MLA)
Wardakhan, Wagnat W.& Samir, Eman M.. The Reaction of Cyclopentanone with Cyanomethylene Reagents : Novel Synthesis of Pyrazole, Thiophene, and Pyridazine Derivatives. Journal of Chemistry No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-471350
American Medical Association (AMA)
Wardakhan, Wagnat W.& Samir, Eman M.. The Reaction of Cyclopentanone with Cyanomethylene Reagents : Novel Synthesis of Pyrazole, Thiophene, and Pyridazine Derivatives. Journal of Chemistry. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-471350
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471350
