Mammary Fat Can Adjust Prolactin Effect on Mammary Epithelial Cells via Leptin and Estrogen
Joint Authors
Feuermann, Yonatan
Shamay, Avi
Mabjeesh, Sameer J.
Source
International Journal of Endocrinology
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-11-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Leptin, like estrogen, is one of the endo/paracrine factors, which are synthesized in and secreted from mature adipocytes.
The roles of the mammary fat pad and mammary adipocytes in the initiation of lactation are not clear.
In this study, we showed that combination of prolactin, leptin and estrogen elevated the expression of the milk protein beta-lactoglobulin.
We also showed that after prolactin stimulate the secretion of leptin from the mammary fat, leptin upregulated the expression of estrogen receptor alpha in the mammary epithelial cells.
Also, prolactin affected aromatase mRNA expression in the bovine mammary fat and we demonstrated that leptin and prolactin can affect cholesterol secretion from explants in culture to the medium.
Therefore, we suggest that prolactin initiates estrogen expression (as represented by aromatase mRNA) in the mammary fat pad, whereas leptin stimulates estrogen receptor alpha expression in the mammary epithelial cells.
We hypothesize that leptin and estrogen, secreted from the mammary fat regulate lactation after stimulation of prolactin.
American Psychological Association (APA)
Feuermann, Yonatan& Mabjeesh, Sameer J.& Shamay, Avi. 2009. Mammary Fat Can Adjust Prolactin Effect on Mammary Epithelial Cells via Leptin and Estrogen. International Journal of Endocrinology،Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-471359
Modern Language Association (MLA)
Feuermann, Yonatan…[et al.]. Mammary Fat Can Adjust Prolactin Effect on Mammary Epithelial Cells via Leptin and Estrogen. International Journal of Endocrinology No. 2009 (2009), pp.1-8.
https://search.emarefa.net/detail/BIM-471359
American Medical Association (AMA)
Feuermann, Yonatan& Mabjeesh, Sameer J.& Shamay, Avi. Mammary Fat Can Adjust Prolactin Effect on Mammary Epithelial Cells via Leptin and Estrogen. International Journal of Endocrinology. 2009. Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-471359
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471359