PPARs in Human Neuroepithelial Tumors : PPAR Ligands as Anticancer Therapies for the Most Common Human Neuroepithelial Tumors
Joint Authors
Benedetti, Elisabetta
Galzio, Renato
Cimini, Annamaria
D'Angelo, Barbara
Cerù, Maria Paola
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Neuroepithelial tumors represent a heterogeneous class of human tumors including benignant and malignant tumors.
The incidence of central nervous system neoplasms ranges from 3.8 to 5.1 cases per 100,000 in the population.
Among malignant neuroepithelial tumors, with regard to PPAR ligands, the most extensively studied were tumors of astrocytic origin and neuroblastoma.
PPARs are expressed in developing and adult neuroepithelial cells, even if with different localization and relative abundance.
The majority of malignant neuroepithelial tumors have poor prognosis and do not respond to conventional therapeutic protocols, therefore, new therapeutic approaches are needed.
Natural and synthetic PPAR ligands may represent a starting point for the formulation of new therapeutic approaches to be used as coadjuvants to the standard therapeutic protocols.
This review will focus on the major studies dealing with PPAR expression in gliomas and neuroblastoma and the therapeutic implications of using PPAR agonists for the treatment of these neoplasms.
American Psychological Association (APA)
Benedetti, Elisabetta& Galzio, Renato& D'Angelo, Barbara& Cerù, Maria Paola& Cimini, Annamaria. 2010. PPARs in Human Neuroepithelial Tumors : PPAR Ligands as Anticancer Therapies for the Most Common Human Neuroepithelial Tumors. PPAR Research،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-471375
Modern Language Association (MLA)
Benedetti, Elisabetta…[et al.]. PPARs in Human Neuroepithelial Tumors : PPAR Ligands as Anticancer Therapies for the Most Common Human Neuroepithelial Tumors. PPAR Research No. 2010 (2010), pp.1-9.
https://search.emarefa.net/detail/BIM-471375
American Medical Association (AMA)
Benedetti, Elisabetta& Galzio, Renato& D'Angelo, Barbara& Cerù, Maria Paola& Cimini, Annamaria. PPARs in Human Neuroepithelial Tumors : PPAR Ligands as Anticancer Therapies for the Most Common Human Neuroepithelial Tumors. PPAR Research. 2010. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-471375
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471375