Dual Antiplatelet Therapy in Secondary Prevention of Ischemic Stroke : A Ghost from the Past or a New Frontier?
Joint Authors
Balucani, Clotilde
Alexandrov, Andrei V.
Barlinn, Kristian
Parnetti, Lucilla
Silvestrini, Mauro
Zivanovic, Zeljko
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
With majority of ischemic strokes attributable to atherothrombosis and many being predictable after transient ischemic attacks (TIA), the role of early secondary prevention with antiplatelet agents is under renewed investigation.
Prior major clinical trials of various secondary stroke prevention regimens pointed to a greater efficacy of dual antiplatelet agents if initiated early from symptom onset.
This paper examines data and rationale behind dual antiplatelet regimens across the completed clinical trials.
The safety of dual antiplatelets approach is of concern, but it could be outweighed, at least in early management, by a greater reduction in recurrence of ischemic events since this risk is “front loaded” after minor stroke or TIA.
Aspirin monotherapy, though considered standard of care, is compared to aspirin-extended release dipiridamole and its combination with clopidogrel in early-phase completed and efficacy-phase ongoing clinical trials.
American Psychological Association (APA)
Balucani, Clotilde& Barlinn, Kristian& Zivanovic, Zeljko& Parnetti, Lucilla& Silvestrini, Mauro& Alexandrov, Andrei V.. 2010. Dual Antiplatelet Therapy in Secondary Prevention of Ischemic Stroke : A Ghost from the Past or a New Frontier?. Stroke Research and Treatment،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-471381
Modern Language Association (MLA)
Balucani, Clotilde…[et al.]. Dual Antiplatelet Therapy in Secondary Prevention of Ischemic Stroke : A Ghost from the Past or a New Frontier?. Stroke Research and Treatment No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-471381
American Medical Association (AMA)
Balucani, Clotilde& Barlinn, Kristian& Zivanovic, Zeljko& Parnetti, Lucilla& Silvestrini, Mauro& Alexandrov, Andrei V.. Dual Antiplatelet Therapy in Secondary Prevention of Ischemic Stroke : A Ghost from the Past or a New Frontier?. Stroke Research and Treatment. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-471381
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471381