Effects of Moderate-to-Severe Impairment of the Estimated Glomerular Filtration Rate and of Proteinuria on the Central Hemodynamics and Arterial Stiffness in Middle-Aged Healthy Japanese Men
Joint Authors
Yamada, Jiko
Tomiyama, Hirofumi
Matsumoto, Chisa
Yamashina, Akira
Yoshida, Masanobu
Shiina, Kazuki
Odaira, Mari
Source
International Journal of Nephrology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-06
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
We evaluated the effects of moderate-to-severe impairment of the estimated glomerular filtration rate (eGFR: 15 to 59 mL/min per 1.73 m2) and of proteinuria on the central hemodynamics and the pulse wave velocity (PWV) in 2244 middle-aged healthy Japanese men who were not receiving any medications for cardiovascular diseases or cardiovascular risk factors.
The adjusted value of the radial augmentation index was higher in the subjects with proteinuria than in those without proteinuria.
On the other hand, this value was similar between the subjects with and without moderate-to-severe impairment of the eGFR.
Not only proteinuria but also moderate-to-severe impairment of the eGFR was associated with increase in the adjusted value of the brachial-ankle PWV.
Thus, proteinuria was found to be an independent risk factor for abnormal central hemodynamics and increased stiffness of the large- to middle-sized arteries, while moderate-to-severe impairment of the eGFR was associated with an increase of the arterial stiffness, but not with abnormality of the central hemodynamics.
American Psychological Association (APA)
Tomiyama, Hirofumi& Odaira, Mari& Matsumoto, Chisa& Yamada, Jiko& Yoshida, Masanobu& Shiina, Kazuki…[et al.]. 2011. Effects of Moderate-to-Severe Impairment of the Estimated Glomerular Filtration Rate and of Proteinuria on the Central Hemodynamics and Arterial Stiffness in Middle-Aged Healthy Japanese Men. International Journal of Nephrology،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-471385
Modern Language Association (MLA)
Tomiyama, Hirofumi…[et al.]. Effects of Moderate-to-Severe Impairment of the Estimated Glomerular Filtration Rate and of Proteinuria on the Central Hemodynamics and Arterial Stiffness in Middle-Aged Healthy Japanese Men. International Journal of Nephrology No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-471385
American Medical Association (AMA)
Tomiyama, Hirofumi& Odaira, Mari& Matsumoto, Chisa& Yamada, Jiko& Yoshida, Masanobu& Shiina, Kazuki…[et al.]. Effects of Moderate-to-Severe Impairment of the Estimated Glomerular Filtration Rate and of Proteinuria on the Central Hemodynamics and Arterial Stiffness in Middle-Aged Healthy Japanese Men. International Journal of Nephrology. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-471385
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471385