Surface TLR2 and TLR4 Expression on Mature Rat Mast Cells Can Be Affected by Some Bacterial Components and Proinflammatory Cytokines

Joint Authors

Brzezińska-Błaszczyk, Ewa
Pietrzak, Anna
Wierzbicki, Maciej
Wiktorska, Magdalena

Source

Mediators of Inflammation

Issue

Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2011-05-02

Country of Publication

Egypt

No. of Pages

11

Main Subjects

Diseases

Abstract EN

The aim of our study was to determine whether some bacterial components as well as some proinflammatory cytokines can affect surface mast cell levels.

By the use of flow cytometry technique, we documented that freshly isolated mature rat peritoneal mast cells do express surface TLR2 and TLR4 protein, but not CD14 molecules, and respond to stimulation with TLR2 and TLR4 ligands by cysteinyl leukotriene generation.

The level of TLR2 protein is modulated by PGN and CCL5 treatment, but not by LPS, LAM, TNF, or IL-6.

Surface mast cell TLR4 expression is affected by LPS, LAM, IL-6, and CCL5.

Considering that TLR-mediated activation conditions not only engaged these cells in antibacterial defense and development of inflammation but also might influence allergic processes, our observations that surface TLR2 and TLR4 expression can be regulated both bacterial components and proinflammatory cytokines seem to be very intriguing and importance.

American Psychological Association (APA)

Pietrzak, Anna& Wierzbicki, Maciej& Wiktorska, Magdalena& Brzezińska-Błaszczyk, Ewa. 2011. Surface TLR2 and TLR4 Expression on Mature Rat Mast Cells Can Be Affected by Some Bacterial Components and Proinflammatory Cytokines. Mediators of Inflammation،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-471386

Modern Language Association (MLA)

Pietrzak, Anna…[et al.]. Surface TLR2 and TLR4 Expression on Mature Rat Mast Cells Can Be Affected by Some Bacterial Components and Proinflammatory Cytokines. Mediators of Inflammation No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-471386

American Medical Association (AMA)

Pietrzak, Anna& Wierzbicki, Maciej& Wiktorska, Magdalena& Brzezińska-Błaszczyk, Ewa. Surface TLR2 and TLR4 Expression on Mature Rat Mast Cells Can Be Affected by Some Bacterial Components and Proinflammatory Cytokines. Mediators of Inflammation. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-471386

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-471386