Subtle Cardiovascular Dysfunction in the Unilateral 6-Hydroxydopamine-Lesioned Rat
Joint Authors
Henderson, J. M.
Matthews, S.
Einstein, R.
Billing, R.
Allbutt, H. N.
Slack, K.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-21
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
The present study evaluated whether the unilateral 6-hydroxydopamine (6-OHDA) model of Parkinson's disease produces autonomic deficits.
Autonomic parameters were assessed by implanting a small radiofrequency telemetry device which measured heart rate variability (HRV), diurnal rhythms of heart rate (HR), core body temperature (cBT) and locomotor activity (LA).
Rats then received 6-OHDA lesion or sham surgery.
6-OHDA lesioned rats exhibited head and body axis biases, defective sensorimotor function (“disengage” test), and prominent apomorphine rotation (all P<.05 versus controls).
Diurnal rhythm of HR was lower for 6-OHDA lesioned rats (n=8) versus controls (n=6; P<.05).
Whilst HR decreased similarly in both groups during the day, there was a greater decrease in HR for the 6-OHDA lesioned rats at night (by 38 b.p.m.
relative to 17 b.p.m.
for controls).
LA and cBT did not differ between surgery groups.
This study indicates the unilateral 6-OHDA model of PD shows subtle signs of cardiovascular autonomic dysfunction.
American Psychological Association (APA)
Slack, K.& Billing, R.& Matthews, S.& Allbutt, H. N.& Einstein, R.& Henderson, J. M.. 2010. Subtle Cardiovascular Dysfunction in the Unilateral 6-Hydroxydopamine-Lesioned Rat. The Scientific World Journal،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-471407
Modern Language Association (MLA)
Slack, K.…[et al.]. Subtle Cardiovascular Dysfunction in the Unilateral 6-Hydroxydopamine-Lesioned Rat. The Scientific World Journal No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-471407
American Medical Association (AMA)
Slack, K.& Billing, R.& Matthews, S.& Allbutt, H. N.& Einstein, R.& Henderson, J. M.. Subtle Cardiovascular Dysfunction in the Unilateral 6-Hydroxydopamine-Lesioned Rat. The Scientific World Journal. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-471407
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471407
