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Mechanism of Oxidative Stress in Neurodegeneration
Joint Authors
Gandhi, Sonia
Abramov, Andrey Y.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-16
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Biological tissues require oxygen to meet their energetic demands.
However, the consumption of oxygen also results in the generation of free radicals that may have damaging effects on cells.
The brain is particularly vulnerable to the effects of reactive oxygen species due to its high demand for oxygen, and its abundance of highly peroxidisable substrates.
Oxidative stress is caused by an imbalance in the redox state of the cell, either by overproduction of reactive oxygen species, or by dysfunction of the antioxidant systems.
Oxidative stress has been detected in a range of neurodegenerative disease, and emerging evidence from in vitro and in vivo disease models suggests that oxidative stress may play a role in disease pathogenesis.
However, the promise of antioxidants as novel therapies for neurodegenerative diseases has not been borne out in clinical studies.
In this review, we critically assess the hypothesis that oxidative stress is a crucial player in common neurodegenerative disease and discuss the source of free radicals in such diseases.
Furthermore, we examine the issues surrounding the failure to translate this hypothesis into an effective clinical treatment.
American Psychological Association (APA)
Gandhi, Sonia& Abramov, Andrey Y.. 2012. Mechanism of Oxidative Stress in Neurodegeneration. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-471427
Modern Language Association (MLA)
Gandhi, Sonia& Abramov, Andrey Y.. Mechanism of Oxidative Stress in Neurodegeneration. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-471427
American Medical Association (AMA)
Gandhi, Sonia& Abramov, Andrey Y.. Mechanism of Oxidative Stress in Neurodegeneration. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-471427
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471427