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The Long-Term Outcomes after Radical Prostatectomy of Patients with Pathologic Gleason 8–10 Disease
Joint Authors
Teng, Brandon
Valencia, Ashley
Gibbons, Robert
Porter, Christopher R.
Lewinshtein, Dan
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
We explored the long-term clinical outcomes including metastases-free survival and prostate cancer-specific survival (PCSS) in patients with pathologic Gleason 8–10 disease after radical prostatectomy (RP).
Methods.
We report on 91 patients with PCSS data with a median followup of 8.2 years after RP performed between 1988 and 1997.
Cox regression and Kaplan-Meier analysis were used to evaluate year of surgery, pathologic stage, and surgical margin status as predictors of PCSM.
Results.
Median age was 65 years (IQR: 61–9), and median PSA was 9.7 ng/ml (IQR: 6.1–13.4).
Of all patients, 62 (68.9%) had stage T3 disease or higher, and 48 (52.7%) had a positive surgical margin.
On multivariate analysis, none of the predictors were statistically significant.
Of all patients, the predicted 10-year BCR-free survival, mets-free survival, and PCSS were 59% (CI: 53%–65%), 88% (CI: 84%–92%), and 94% (CI: 91%–97%), respectively.
Conclusions.
We have demonstrated that cancer control is durable even 10 years after RP in those with pathologic Gleason 8–10 disease.
Although 40% will succumb to BCR, only 6% of patients died of their disease.
These results support the use of RP for patients with high-risk localized prostate cancer.
American Psychological Association (APA)
Lewinshtein, Dan& Teng, Brandon& Valencia, Ashley& Gibbons, Robert& Porter, Christopher R.. 2011. The Long-Term Outcomes after Radical Prostatectomy of Patients with Pathologic Gleason 8–10 Disease. Advances in Urology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-471439
Modern Language Association (MLA)
Lewinshtein, Dan…[et al.]. The Long-Term Outcomes after Radical Prostatectomy of Patients with Pathologic Gleason 8–10 Disease. Advances in Urology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-471439
American Medical Association (AMA)
Lewinshtein, Dan& Teng, Brandon& Valencia, Ashley& Gibbons, Robert& Porter, Christopher R.. The Long-Term Outcomes after Radical Prostatectomy of Patients with Pathologic Gleason 8–10 Disease. Advances in Urology. 2011. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-471439
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471439