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An Investigation of Small GTPases in relation to Liver Tumorigenesis Using Traditional Chinese Medicine
Joint Authors
Lee, Wen-Yuan
Chen, Kuen-Bao
Chen, Calvin Yu-Chian
Chan, Yueh-Chiu
Hung, Tzu-Chieh
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-19
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Recently, an important topic of liver tumorigenesis had been published in 2013.
In this report, Ras and Rho had defined the relation of liver tumorigenesis.
The traditional Chinese medicine (TCM) database has been screened for molecular compounds by simulating molecular docking and molecular dynamics to regulate Ras and liver tumorigenesis.
Saussureamine C, S-allylmercaptocysteine, and Tryptophan are selected based on the highest docking score than other TCM compounds.
The molecular dynamics are helpful in the analysis and detection of protein-ligand interactions.
Based on the docking poses, hydrophobic interactions, and hydrogen bond variations, this research surmises are the main regions of important amino acids in Ras.
In addition to the detection of TCM compound efficacy, we suggest Saussureamine C is better than the others for protein-ligand interaction.
American Psychological Association (APA)
Hung, Tzu-Chieh& Lee, Wen-Yuan& Chen, Kuen-Bao& Chan, Yueh-Chiu& Chen, Calvin Yu-Chian. 2014. An Investigation of Small GTPases in relation to Liver Tumorigenesis Using Traditional Chinese Medicine. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-471450
Modern Language Association (MLA)
Hung, Tzu-Chieh…[et al.]. An Investigation of Small GTPases in relation to Liver Tumorigenesis Using Traditional Chinese Medicine. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-471450
American Medical Association (AMA)
Hung, Tzu-Chieh& Lee, Wen-Yuan& Chen, Kuen-Bao& Chan, Yueh-Chiu& Chen, Calvin Yu-Chian. An Investigation of Small GTPases in relation to Liver Tumorigenesis Using Traditional Chinese Medicine. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-471450
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471450