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A Comprehensive Study of Progressive Cytogenetic Alterations in Clear Cell Renal Cell Carcinoma and a New Model for ccRCC Tumorigenesis and Progression
Joint Authors
Zhang, Zhongfa
Wondergem, Bill
Dykema, Karl
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-07-05
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
We present a comprehensive study of cytogenetic alterations that occur during the progression of clear cell renal cell carcinoma (ccRCC).
We used high-density high-throughput Affymetrix 100 K SNP arrays to obtain the whole genome SNP copy number information from 71 pretreatment tissue samples with RCC tumors; of those, 42 samples were of human ccRCC subtype.
We analyzed patterns of cytogenetic loss and gain from different RCC subtypes and in particular, different stages and grades of ccRCC tumors, using a novel algorithm that we have designed.
Based on patterns of cytogenetic alterations in chromosomal regions with frequent losses and gains, we inferred the involvement of candidate genes from these regions in ccRCC tumorigenesis and development.
We then proposed a new model of ccRCC tumorigenesis and progression.
Our study serves as a comprehensive overview of cytogenetic alterations in a collection of 572 ccRCC tumors from diversified studies and should facilitate the search for specific genes associated with the disease.
American Psychological Association (APA)
Zhang, Zhongfa& Wondergem, Bill& Dykema, Karl. 2010. A Comprehensive Study of Progressive Cytogenetic Alterations in Clear Cell Renal Cell Carcinoma and a New Model for ccRCC Tumorigenesis and Progression. Advances in Bioinformatics،Vol. 2010, no. 2010, pp.1-14.
https://search.emarefa.net/detail/BIM-471463
Modern Language Association (MLA)
Zhang, Zhongfa…[et al.]. A Comprehensive Study of Progressive Cytogenetic Alterations in Clear Cell Renal Cell Carcinoma and a New Model for ccRCC Tumorigenesis and Progression. Advances in Bioinformatics No. 2010 (2010), pp.1-14.
https://search.emarefa.net/detail/BIM-471463
American Medical Association (AMA)
Zhang, Zhongfa& Wondergem, Bill& Dykema, Karl. A Comprehensive Study of Progressive Cytogenetic Alterations in Clear Cell Renal Cell Carcinoma and a New Model for ccRCC Tumorigenesis and Progression. Advances in Bioinformatics. 2010. Vol. 2010, no. 2010, pp.1-14.
https://search.emarefa.net/detail/BIM-471463
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471463