Role of MicroRNA-1 in Human Cancer and Its Therapeutic Potentials
Joint Authors
Kan, Quancheng
Han, Chao
Yu, Zujiang
Duan, Zhenfeng
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-18
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
While the mechanisms of human cancer development are not fully understood, evidence of microRNA (miRNA, miR) dysregulation has been reported in many human diseases, including cancer.
miRs are small noncoding RNA molecules that regulate posttranscriptional gene expression by binding to complementary sequences in the specific region of gene mRNAs, resulting in downregulation of gene expression.
Not only are certain miRs consistently dysregulated across many cancers, but they also play critical roles in many aspects of cell growth, proliferation, metastasis, apoptosis, and drug resistance.
Recent studies from our group and others revealed that miR-1 is frequently downregulated in various types of cancer.
Through targeting multiple oncogenes and oncogenic pathways, miR-1 has been demonstrated to be a tumor suppressor gene that represses cancer cell proliferation and metastasis and promotes apoptosis by ectopic expression.
In this review, we highlight recent findings on the aberrant expression and functional significance of miR-1 in human cancers and emphasize its significant values for therapeutic potentials.
American Psychological Association (APA)
Han, Chao& Yu, Zujiang& Duan, Zhenfeng& Kan, Quancheng. 2014. Role of MicroRNA-1 in Human Cancer and Its Therapeutic Potentials. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-471469
Modern Language Association (MLA)
Han, Chao…[et al.]. Role of MicroRNA-1 in Human Cancer and Its Therapeutic Potentials. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-471469
American Medical Association (AMA)
Han, Chao& Yu, Zujiang& Duan, Zhenfeng& Kan, Quancheng. Role of MicroRNA-1 in Human Cancer and Its Therapeutic Potentials. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-471469
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471469