Potential Antioxidant Role of Tridham in Managing Oxidative Stress against Aflatoxin-B1-Induced Experimental Hepatocellular Carcinoma
Joint Authors
Palanivelu, Shanthi
Panchanadham, Sachdanandam
Jaganathan, Ravindran
Ravinayagam, Vijaya
Source
International Journal of Hepatology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Hepatocellular carcinoma (HCC) is one of the most fatal cancers due to delayed diagnosis and lack of effective treatment options.
Significant exposure to Aflatoxin B1 (AFB1), a potent hepatotoxic and hepatocarcinogenic mycotoxin, plays a major role in liver carcinogenesis through oxidative tissue damage and p53 mutation.
The present study emphasizes the anticarcinogenic effect of Tridham (TD), a polyherbal traditional medicine, on AFB1-induced HCC in male Wistar rats.
AFB1-administered HCC-bearing rats (Group II) showed increased levels of lipid peroxides (LPOs), thiobarbituric acid substances (TBARs), and protein carbonyls (PCOs) and decreased levels of enzymic and nonenzymic antioxidants when compared to control animals (Group I).
Administration of TD orally (300 mg/kg body weight/day) for 45 days to HCC-bearing animals (Group III) significantly reduced the tissue damage accompanied by restoration of the levels of antioxidants.
Histological observation confirmed the induction of tumour in Group II animals and complete regression of tumour in Group III animals.
This study highlights the potent antioxidant properties of TD which contribute to its therapeutic effect in AFB1-induced HCC in rats.
American Psychological Association (APA)
Ravinayagam, Vijaya& Jaganathan, Ravindran& Panchanadham, Sachdanandam& Palanivelu, Shanthi. 2012. Potential Antioxidant Role of Tridham in Managing Oxidative Stress against Aflatoxin-B1-Induced Experimental Hepatocellular Carcinoma. International Journal of Hepatology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-471470
Modern Language Association (MLA)
Ravinayagam, Vijaya…[et al.]. Potential Antioxidant Role of Tridham in Managing Oxidative Stress against Aflatoxin-B1-Induced Experimental Hepatocellular Carcinoma. International Journal of Hepatology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-471470
American Medical Association (AMA)
Ravinayagam, Vijaya& Jaganathan, Ravindran& Panchanadham, Sachdanandam& Palanivelu, Shanthi. Potential Antioxidant Role of Tridham in Managing Oxidative Stress against Aflatoxin-B1-Induced Experimental Hepatocellular Carcinoma. International Journal of Hepatology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-471470
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471470