Identification and Characterization of Genes Involved in Leishmania Pathogenesis : The Potential for Drug Target Selection
Joint Authors
Gannavaram, Sreenivas
Debrabant, Alain
Dey, Ranadhir
Nakhasi, Hira L.
Duncan, Robert
Lakhal-Naouar, Ines
Source
Molecular Biology International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Identifying and characterizing Leishmania donovani genes and the proteins they encode for their role in pathogenesis can reveal the value of this approach for finding new drug targets.
Effective drug targets are likely to be proteins differentially expressed or required in the amastigote life cycle stage found in the patient.
Several examples and their potential for chemotherapeutic disruption are presented.
A pathway nearly ubiquitous in living cells targeted by anticancer drugs, the ubiquitin system, is examined.
New findings in ubiquitin and ubiquitin-like modifiers in Leishmania show how disruption of those pathways could point to additional drug targets.
The programmed cell death pathway, now recognized among protozoan parasites, is reviewed for some of its components and evidence that suggests they could be targeted for antiparasitic drug therapy.
Finally, the endoplasmic reticulum quality control system is involved in secretion of many virulence factors.
How disruptions in this pathway reduce virulence as evidence for potential drug targets is presented.
American Psychological Association (APA)
Duncan, Robert& Gannavaram, Sreenivas& Dey, Ranadhir& Debrabant, Alain& Lakhal-Naouar, Ines& Nakhasi, Hira L.. 2011. Identification and Characterization of Genes Involved in Leishmania Pathogenesis : The Potential for Drug Target Selection. Molecular Biology International،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-471478
Modern Language Association (MLA)
Duncan, Robert…[et al.]. Identification and Characterization of Genes Involved in Leishmania Pathogenesis : The Potential for Drug Target Selection. Molecular Biology International No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-471478
American Medical Association (AMA)
Duncan, Robert& Gannavaram, Sreenivas& Dey, Ranadhir& Debrabant, Alain& Lakhal-Naouar, Ines& Nakhasi, Hira L.. Identification and Characterization of Genes Involved in Leishmania Pathogenesis : The Potential for Drug Target Selection. Molecular Biology International. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-471478
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471478