Yeast as a Model System to Study Tau Biology
Joint Authors
Franssens, Vanessa
De Vos, Ann
Winderickx, Joris
Verduyckt, Mathias
Van den Brande, Jeff
Anandhakumar, Jayamani
Swinnen, Erwin
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-06
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Hyperphosphorylated and aggregated human protein tau constitutes a hallmark of a multitude of neurodegenerative diseases called tauopathies, exemplified by Alzheimer's disease.
In spite of an enormous amount of research performed on tau biology, several crucial questions concerning the mechanisms of tau toxicity remain unanswered.
In this paper we will highlight some of the processes involved in tau biology and pathology, focusing on tau phosphorylation and the interplay with oxidative stress.
In addition, we will introduce the development of a human tau-expressing yeast model, and discuss some crucial results obtained in this model, highlighting its potential in the elucidation of cellular processes leading to tau toxicity.
American Psychological Association (APA)
De Vos, Ann& Anandhakumar, Jayamani& Van den Brande, Jeff& Verduyckt, Mathias& Franssens, Vanessa& Winderickx, Joris…[et al.]. 2011. Yeast as a Model System to Study Tau Biology. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-471525
Modern Language Association (MLA)
De Vos, Ann…[et al.]. Yeast as a Model System to Study Tau Biology. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-16.
https://search.emarefa.net/detail/BIM-471525
American Medical Association (AMA)
De Vos, Ann& Anandhakumar, Jayamani& Van den Brande, Jeff& Verduyckt, Mathias& Franssens, Vanessa& Winderickx, Joris…[et al.]. Yeast as a Model System to Study Tau Biology. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-471525
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471525