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Differential Changes of Aorta and Carotid Vasodilation in Type 2 Diabetic GK and OLETF Rats : Paradoxical Roles of Hyperglycemia and Insulin
Joint Authors
Zhong, Mei-Fang
Chen, Hong
Shen, Wei-Li
Higashino, Hideaki
Kamenov, Zdravko A.
Nakamura, Kyoko
Tabuchi, Masaki
Yang, Jie
Chen, Yi-Chen
Zhang, Chuan
He, Jin
Qiao, Cong-Zhen
Source
Experimental Diabetes Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-01
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
We investigated large vessel function in lean Goto-Kakizaki diabetic rats (GK) and Otsuka Long-Evans Tokushima Fatty diabetic rats (OLETF) with possible roles of hyperglycemia/hyperosmolarity and insulin.
Both young and old GK showed marked hyperglycemia with normal insulin level and well-preserved endothelium-dependent and endothelium-independent vasodilation in aorta and carotid artery.
There were significant elevations in endothelial/inducible nitric oxide synthase (eNOS/iNOS) and inducible/constitutive heme oxygenase (HO-1/HO-2) in GK.
The endothelium-dependent vasodilation in GK was inhibited partly by NOS blockade and completely by simultaneous blocking of HO and NOS.
In contrast, OLETF showed hyperinsulinemia and mild hyperglycemia but significant endothelium dysfunction beginning at early ages with concomitantly reduced eNOS.
Insulin injection corrected hyperglycemia in GK but induced endothelium dysfunction and intima hyperplasia.
Hyperglycemia/hyperosmolarity in vitro enhanced vessel eNOS/HO.
We suggest that hyperinsulinemia plays a role in endothelium dysfunction in obese diabetic OLETF, while hyperglycemia/hyperosmolarity-induced eNOS/HO upregulation participates in the adaptation of endothelium function in lean diabetic GK.
American Psychological Association (APA)
Zhong, Mei-Fang& Shen, Wei-Li& Tabuchi, Masaki& Nakamura, Kyoko& Chen, Yi-Chen& Qiao, Cong-Zhen…[et al.]. 2011. Differential Changes of Aorta and Carotid Vasodilation in Type 2 Diabetic GK and OLETF Rats : Paradoxical Roles of Hyperglycemia and Insulin. Experimental Diabetes Research،Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-471531
Modern Language Association (MLA)
Zhong, Mei-Fang…[et al.]. Differential Changes of Aorta and Carotid Vasodilation in Type 2 Diabetic GK and OLETF Rats : Paradoxical Roles of Hyperglycemia and Insulin. Experimental Diabetes Research No. 2012 (2012), pp.1-16.
https://search.emarefa.net/detail/BIM-471531
American Medical Association (AMA)
Zhong, Mei-Fang& Shen, Wei-Li& Tabuchi, Masaki& Nakamura, Kyoko& Chen, Yi-Chen& Qiao, Cong-Zhen…[et al.]. Differential Changes of Aorta and Carotid Vasodilation in Type 2 Diabetic GK and OLETF Rats : Paradoxical Roles of Hyperglycemia and Insulin. Experimental Diabetes Research. 2011. Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-471531
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471531