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DNA Interaction Studies of a New Platinum(II) Complex Containing Different Aromatic Dinitrogen Ligands
Joint Authors
Alizadeh, Robabeh
Mohammadi, Somaye
Shahabadi, Nahid
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
A new mononuclear Pt(II) complex, [Pt(DMP)(DIP)]Cl2.H2O, in which DMP is 4,4-dimethyl-2,2-bipyridine and DIP is 4,7-diphenyl-1,10-phenantroline, has been synthesized and characterized by physicochemical and spectroscopic methods.
The binding interaction of this complex with calf thymus DNA (CT-DNA) was investigated using fluorimetry, spectrophotometry, circular dichroism, viscosimetry and cyclic voltametry (CV).
UV-VIS spectrum showed 4 nm bathochromic shift of the absorption band at 280 nm along with significant hypochromicity for the absorption band of the complex.
The intrnisic binding constant (Kb=2×104 M-1) is more in keeping with intercalators and suggests this binding mode.
The viscosity measurements showed that the complex-DNA interaction can be hydrophobic and confirm intercalation.
Moreover, the complex induced detectable changes in the CD spectrum of CT-DNA.
The fluorescence studies revealed that the probable quenching mechanism of fluorescence of the complex by CT-DNA is static quenching.
The thermodynamic parameters (ΔH>0 and ΔS>0) showed that main interaction with hydrogenic forces occurred that is intercalation mode.
Also, CV results confirm this mode because, with increasing the CT-DNA concentration, shift to higher potential was observed.
American Psychological Association (APA)
Shahabadi, Nahid& Mohammadi, Somaye& Alizadeh, Robabeh. 2011. DNA Interaction Studies of a New Platinum(II) Complex Containing Different Aromatic Dinitrogen Ligands. Bioinorganic Chemistry and Applications،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-471564
Modern Language Association (MLA)
Shahabadi, Nahid…[et al.]. DNA Interaction Studies of a New Platinum(II) Complex Containing Different Aromatic Dinitrogen Ligands. Bioinorganic Chemistry and Applications No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-471564
American Medical Association (AMA)
Shahabadi, Nahid& Mohammadi, Somaye& Alizadeh, Robabeh. DNA Interaction Studies of a New Platinum(II) Complex Containing Different Aromatic Dinitrogen Ligands. Bioinorganic Chemistry and Applications. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-471564
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471564