Tumor Necrosis Factor Receptor 1 Expression Is Upregulated in Dendritic Cells in Patients with Chronic HCV Who Respond to Therapy
Joint Authors
Thiele, Dwain L.
Cubillas, Raul
Karandikar, Nitin J.
Phillips, Frances
Brown, Geri R.
Kintner, Katherine
Source
Hepatitis Research and Treatment
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The present studies assessed the level of tumor necrosis factor receptor (TNFR) expression in peripheral blood mononuclear cells (PBMCs) subsets from patients with chronic HCV undergoing interferon α/ribavirin-based therapy (Ifn/R).
Methods.
TNFR family member mRNA expression was determined using quantitative real-time PCR assays (RTPCRs) in PBMC from 39 HCV+ patients and 21 control HCV− patients.
Further subset analysis of HCV + patients (untreated (U), sustained virological responders (SVR), and nonresponders (NR)/relapsers (Rel)) PBMC was performed via staining with anti-CD123, anti-CD33, anti-TNFR1 or via RTPCR for TNFR1 mRNA.
Results.
A similar level of TNFR1 mRNA in PBMC from untreated HCV+ genotype 1 patients and controls was noted.
TNFR1 and TNFR2 mRNA levels in PBMC from HCV+ patients with SVR were statistically different than levels in HCV(−) patients.
A significant difference was noted between the peak values of TNFR1 of the CD123+ PBMC isolated from SVR and the NR/Rel.
Conclusion.
Upregulation of TNFR1 expression, occurring in a specific subset of CD123+ dendritic cells, appeared in HCV+ patients with SVR.
American Psychological Association (APA)
Cubillas, Raul& Kintner, Katherine& Phillips, Frances& Karandikar, Nitin J.& Thiele, Dwain L.& Brown, Geri R.. 2010. Tumor Necrosis Factor Receptor 1 Expression Is Upregulated in Dendritic Cells in Patients with Chronic HCV Who Respond to Therapy. Hepatitis Research and Treatment،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-471565
Modern Language Association (MLA)
Cubillas, Raul…[et al.]. Tumor Necrosis Factor Receptor 1 Expression Is Upregulated in Dendritic Cells in Patients with Chronic HCV Who Respond to Therapy. Hepatitis Research and Treatment No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-471565
American Medical Association (AMA)
Cubillas, Raul& Kintner, Katherine& Phillips, Frances& Karandikar, Nitin J.& Thiele, Dwain L.& Brown, Geri R.. Tumor Necrosis Factor Receptor 1 Expression Is Upregulated in Dendritic Cells in Patients with Chronic HCV Who Respond to Therapy. Hepatitis Research and Treatment. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-471565
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471565