Impact of Short-Term Systemic Hypoxia on Phagocytosis, Cytokine Production, and Transcription Factor Activation in Peripheral Blood Cells
Joint Authors
Jung, Christian
Figulla, Hans Reiner
Lauten, Alexander
Fritzenwanger, Michael
Goebel, Bjoern
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Hypoxia frequently associated with certain physiologic and pathologic conditions influences numerous cellular functions.
Because the effects of short-term hypoxia are incompletely understood, we examined phagocytosis and cytokine production as well as the activation of the transcription factors HIF-1 and NFκB in peripheral blood cells of healthy volunteers exposed to an oxygen concentration equivalent to that found at a height of 5500 m.
Furthermore, we analysed plasma HIF-1 and serum concentrations of various HIF-1-dependent genes.
Results showed that short-term hypoxia increased phagocytosis in neutrophils without affecting monocyte phagocytosis.
Hypoxia decreased basal TNFα concentration in monocytes and basal interferon γ concentration in CD4+ T lymphocytes.
In contrast, plasma HIF and serum VEGF concentrations were not affected by hypoxia, although serum EPO concentration was raised.
In PBMC, hypoxia increased cytosolic HIF-1 concentration without affecting nuclear HIF-1 concentration and led to a rise in the nuclear NFκB in PBMC.
Our results show that short-term hypoxia affects immune functions in healthy individuals.
Furthermore, we speculate that the effects of hypoxia are not due to HIF-1, but are caused by the activation of NFκB .
American Psychological Association (APA)
Fritzenwanger, Michael& Jung, Christian& Goebel, Bjoern& Lauten, Alexander& Figulla, Hans Reiner. 2011. Impact of Short-Term Systemic Hypoxia on Phagocytosis, Cytokine Production, and Transcription Factor Activation in Peripheral Blood Cells. Mediators of Inflammation،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-471591
Modern Language Association (MLA)
Fritzenwanger, Michael…[et al.]. Impact of Short-Term Systemic Hypoxia on Phagocytosis, Cytokine Production, and Transcription Factor Activation in Peripheral Blood Cells. Mediators of Inflammation No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-471591
American Medical Association (AMA)
Fritzenwanger, Michael& Jung, Christian& Goebel, Bjoern& Lauten, Alexander& Figulla, Hans Reiner. Impact of Short-Term Systemic Hypoxia on Phagocytosis, Cytokine Production, and Transcription Factor Activation in Peripheral Blood Cells. Mediators of Inflammation. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-471591
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471591