Parkinson’s Disease and Autophagy
Joint Authors
Sánchez-Andrés, Juan Vicente
Sánchez-Pérez, Ana María
Claramonte-Clausell, Berta
Herrero, María Trinidad
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-17
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
It is generally accepted that a correlation between neurodegenerative disease and protein aggregation in the brain exists; however, a causal relationship has not been elucidated.
In neurons, failure of autophagy may result in the accumulation of aggregate-prone proteins and subsequent neurodegeneration.
Thus, pharmacological induction of autophagy to enhance the clearance of intracytoplasmic aggregate-prone proteins has been considered as a therapeutic strategy to ameliorate pathology in cell and animal models of neurodegenerative disorders.
However, autophagy has also been found to be a factor in the onset of these diseases, which raises the question of whether autophagy induction is an effective therapeutic strategy, or, on the contrary, can result in cell death.
In this paper, we will first describe the autophagic machinery, and we will consider the literature to discuss the neuroprotective effects of autophagy.
American Psychological Association (APA)
Sánchez-Pérez, Ana María& Claramonte-Clausell, Berta& Sánchez-Andrés, Juan Vicente& Herrero, María Trinidad. 2012. Parkinson’s Disease and Autophagy. ISRN Economics،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-471594
Modern Language Association (MLA)
Sánchez-Pérez, Ana María…[et al.]. Parkinson’s Disease and Autophagy. ISRN Economics No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-471594
American Medical Association (AMA)
Sánchez-Pérez, Ana María& Claramonte-Clausell, Berta& Sánchez-Andrés, Juan Vicente& Herrero, María Trinidad. Parkinson’s Disease and Autophagy. ISRN Economics. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-471594
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471594