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Dissection of Biological Property of Chinese Acupuncture Point Zusanli Based on Long-Term Treatment via Modulating Multiple Metabolic Pathways
Joint Authors
Sun, Hui
Zhang, Aihua
Wang, Xijun
Xie, Ning
Meng, Xiangcai
Liu, Li
Yan, Guangli
Zhang, Yingzhi
Cheng, Weiping
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-01
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Acupuncture has a history of over 3000 years and is a traditional Chinese medical therapy that uses hair-thin metal needles to puncture the skin at specific points on the body to promote wellbeing, while its molecular mechanism and ideal biological pathways are still not clear.
High-throughput metabolomics is the global assessment of endogenous metabolites within a biologic system and can potentially provide a more accurate snap shot of the actual physiological state.
We hypothesize that acupuncture-treated human would produce unique characterization of metabolic phenotypes.
In this study, UPLC/ESI-HDMS coupled with pattern recognition methods and system analysis were carried out to investigate the mechanism and metabolite biomarkers for acupuncture treatment at “Zusanli” acupoint (ST-36) as a case study.
The top 5 canonical pathways including alpha-linolenic acid metabolism, d-glutamine and d-glutamate metabolism, citrate cycle, alanine, aspartate, and glutamate metabolism, and vitamin B6 metabolism pathways were acutely perturbed, and 53 differential metabolites were identified by chemical profiling and may be useful to clarify the physiological basis and mechanism of ST-36.
More importantly, network construction has led to the integration of metabolites associated with the multiple perturbation pathways.
Urine metabolic profiling might be a promising method to investigate the molecular mechanism of acupuncture.
American Psychological Association (APA)
Yan, Guangli& Zhang, Aihua& Sun, Hui& Cheng, Weiping& Meng, Xiangcai& Liu, Li…[et al.]. 2013. Dissection of Biological Property of Chinese Acupuncture Point Zusanli Based on Long-Term Treatment via Modulating Multiple Metabolic Pathways. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-471608
Modern Language Association (MLA)
Yan, Guangli…[et al.]. Dissection of Biological Property of Chinese Acupuncture Point Zusanli Based on Long-Term Treatment via Modulating Multiple Metabolic Pathways. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-471608
American Medical Association (AMA)
Yan, Guangli& Zhang, Aihua& Sun, Hui& Cheng, Weiping& Meng, Xiangcai& Liu, Li…[et al.]. Dissection of Biological Property of Chinese Acupuncture Point Zusanli Based on Long-Term Treatment via Modulating Multiple Metabolic Pathways. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-471608
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471608