Prevalence of Occult Hepatitis C Virus in Egyptian Patients with Chronic Lymphoproliferative Disorders
Joint Authors
Nasr, Aml S.
Mattar, Mervat M.
El Rawi, Rasha Sayed
El Zanaty, Taher
Youssef, Samar Samir
Source
Hepatitis Research and Treatment
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-12
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Occult hepatitis C virus infection (OCI) was identified as a new form of Hepatitis C virus (HCV), characterized by undetectable HCV antibodies and HCV RNA in serum, while HCV RNA is detectable in liver and peripheral blood cells only.
Aim.
The aim of this study was to investigate the occurrence of OCI in Egyptian patients with lymphoproliferative disorders (LPDs) and to compare its prevalence with that of HCV in those patients.
Subjects and Methods.
The current study included 100 subjects, 50 of them were newly diagnosed cases having different lymphoproliferative disorders (patients group), and 50 were apparently healthy volunteers (controls group).
HCV antibodies were detected by ELISA, HCV RNA was detected in serum and peripheral blood mononuclear cells (PBMCs) by reverse transcription polymerase chain reaction(RT-PCR), and HCV genotype was detected by INNO-LiPA.
Results.
OCI was detected in 20% of patients group, compared to only 4% OCI in controls group.
HCV was detected in 26% of patients group with a slightly higher prevalence.
There was a male predominance in both HCV and OCI.
All HCV positive patients were genotype 4.
Conclusion.
Our data revealed occurrence of occult HCV infection in Egyptian LPD patients at a prevalence of 20% compared to 26% of HCV.
American Psychological Association (APA)
Youssef, Samar Samir& Nasr, Aml S.& El Zanaty, Taher& El Rawi, Rasha Sayed& Mattar, Mervat M.. 2012. Prevalence of Occult Hepatitis C Virus in Egyptian Patients with Chronic Lymphoproliferative Disorders. Hepatitis Research and Treatment،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-471616
Modern Language Association (MLA)
Youssef, Samar Samir…[et al.]. Prevalence of Occult Hepatitis C Virus in Egyptian Patients with Chronic Lymphoproliferative Disorders. Hepatitis Research and Treatment No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-471616
American Medical Association (AMA)
Youssef, Samar Samir& Nasr, Aml S.& El Zanaty, Taher& El Rawi, Rasha Sayed& Mattar, Mervat M.. Prevalence of Occult Hepatitis C Virus in Egyptian Patients with Chronic Lymphoproliferative Disorders. Hepatitis Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-471616
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471616