Bortezomib-Induced Bronchiolitis Obliterans Organizing Pneumonia

Abstract EN

Introduction.

Bortezomib is a proteasome inhibitor indicated for the treatment of multiple myeloma patients.

The most frequent side effects are gastrointestinal and neurological.

Serious pulmonary complications have been described rarely.

Observation.

This case involves a 74-year-old man suffering from IgG Kappa myeloma treated with bortezomib, melphalan, and dexamethasone.

After administering chemotherapy, the patient developed an acute respiratory distress syndrome (ARDS).

A surgical pulmonary biopsy proved the existence of bronchiolitis obliterans organizing pneumonia (BOOP) lesions.

Systemic corticotherapy led to a rapid improvement in the patient’s condition.

Conclusion.

This is the first reported histologically confirmed case of bortezomid-induced BOOP.

Faced with severe respiratory symptoms in the absence of other etiologies, complications due to bortezomid treatment should be evoked and corticotherapy considered.