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Mesenchymal Migration as a Therapeutic Target in Glioblastoma
Joint Authors
Zhong, Jessie
O'Neill, Geraldine M.
Kellie, Stewart J.
Paul, Andre
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-21
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Extensive infiltration of the surrounding healthy brain tissue is a cardinal feature of glioblastomas, highly lethal brain tumors.
Deep infiltration by the glioblastoma cells renders complete surgical excision difficult and contemporary adjuvant therapies have had little impact on long-term survival.
Thus, deep infiltration and resistance to irradiation and chemotherapy remain a major cause of patient mortality.
Modern therapies specifically targeted to this unique aspect of glioblastoma cell biology hold significant promise to substantially improve survival rates for glioblastoma patients.
In the present paper, we focus on the role of adhesion signaling molecules and the actin cytoskeleton in the mesenchymal mode of motility that characterizes invading glioblastoma cells.
We then review current approaches to targeting these elements of the glioblastoma cell migration machinery and discuss other aspects of cell migration that may improve the treatment of infiltrating glioblastoma.
American Psychological Association (APA)
Zhong, Jessie& Paul, Andre& Kellie, Stewart J.& O'Neill, Geraldine M.. 2010. Mesenchymal Migration as a Therapeutic Target in Glioblastoma. Journal of Oncology،Vol. 2010, no. 2010, pp.1-17.
https://search.emarefa.net/detail/BIM-471635
Modern Language Association (MLA)
Zhong, Jessie…[et al.]. Mesenchymal Migration as a Therapeutic Target in Glioblastoma. Journal of Oncology No. 2010 (2010), pp.1-17.
https://search.emarefa.net/detail/BIM-471635
American Medical Association (AMA)
Zhong, Jessie& Paul, Andre& Kellie, Stewart J.& O'Neill, Geraldine M.. Mesenchymal Migration as a Therapeutic Target in Glioblastoma. Journal of Oncology. 2010. Vol. 2010, no. 2010, pp.1-17.
https://search.emarefa.net/detail/BIM-471635
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471635